TY - JOUR T1 - Outer retinal layer thickness in patients with glaucoma with horizontal hemifield visual field defects JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1217 LP - 1222 DO - 10.1136/bjophthalmol-2018-312753 VL - 103 IS - 9 AU - Jayme R Vianna AU - Ziad Butty AU - Lucas A Torres AU - Glen P Sharpe AU - Donna M Hutchison AU - Lesya M Shuba AU - Marcelo T Nicolela AU - Balwantray C Chauhan Y1 - 2019/09/01 UR - http://bjo.bmj.com/content/103/9/1217.abstract N2 - Background/Aims To determine the effect of glaucoma on outer retinal layer thickness in eyes with horizontal hemifield visual field (VF) defects.Methods We conducted a cross-sectional study in glaucomatous eyes with repeatable (in three or examinations) horizontal hemifield VF (programme 24–2) defect defined as: all five nasal VF locations immediately either above or below the horizontal midline abnormal in the pattern deviation plot with p<0.5%; no mirror-image adjacent 5 VF locations abnormal in the pattern deviation plot and no non-edge VF locations in the non-affected hemifield abnormal in the pattern deviation plot with p<1%. We used optical coherence tomography to measure thickness of each retinal layer in the temporal macula (12° horizontally and 24° vertically) and computed the absolute (µm) and relative (%) intraindividual asymmetry between the perimetrically normal and abnormal hemimacula.Results We included 10 eyes of 8 patients with median age of 67 years and median VF mean deviation of −8.85 dB. The nerve fibre, ganglion cell and inner plexiform layers were significantly thinner in the perimetrically abnormal hemimacula (median asymmetry of –6.4, –11.5 and −3.8 µm, (corresponding to –27.7, –40.5 and −15.7 %), respectively, all p≤0.01). The inner nuclear layer was slightly thicker in the perimetrically abnormal hemimacula (median asymmetry of 1.3 µm (5.0 %), p=0.01). The outer plexiform, outer nuclear and photoreceptor layers asymmetry values were negligible.Conclusion Our study showed no evidence that glaucoma has an effect on the outer retinal layer thickness. In contrast, a large impact was observed in inner layer thickness. ER -