PT  - JOURNAL ARTICLE
AU  - Laure Malosse
AU  - Hélène Rousseau
AU  - Cédric Baumann
AU  - Karine Angioi
AU  - Bertrand Leroy
AU  - Florian Sennlaub
AU  - Jean-Paul Berrod
AU  - Jean-Baptiste Conart
TI  - Prevalence and risk factors for outer retinal layer damage after macula-off retinal detachment
AID  - 10.1136/bjophthalmol-2019-314236
DP  - 2019 Aug 28
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2019-314236
4099  - http://bjo.bmj.com/content/early/2019/08/27/bjophthalmol-2019-314236.short
4100  - http://bjo.bmj.com/content/early/2019/08/27/bjophthalmol-2019-314236.full
AB  - Purpose To report the prevalence of outer retinal layer (ORL) damage after macula-off rhegmatogenous retinal detachment (RRD) surgery and to determine its associated preoperative risk factors.Methods 253 eyes successfully operated for macula-off RRD were included in the study. The integrity of the external limiting membrane (ELM), ellipsoid zone (EZ) and cone interdigitation zone (CIZ) of the photoreceptors was assessed at 1 month and 6 months using spectral-domain optical coherence tomography. Risk factors were analysed using univariate and multivariate logistic regression. The correlation between ORL integrity and visual outcomes was also evaluated.Results CIZ, EZ and ELM defects were found in, respectively, 198 (93.4%) eyes, 100 (47.2%) eyes, 64 (30.2%) eyes at 1 month and in 160 (63.2%) eyes, 44 (17.4%) eyes and 18 (7.1%) eyes at 6 months. In multivariate analysis, duration of macular detachment was the only factor associated with ORL damage at 6 months (p=0.007). Best-corrected visual acuity significantly improved from 0.5±0.3 at 1 month to 0.3±0.3 logarithm of minimal angle of resolution at 6 months (p<0.001) and was strongly correlated with the number of affected bands (p<0.001).Conclusion Prevalence of outer retinal band defects substantially decreased through the study period, confirming the ability of photoreceptors to recover over time. However, shorter interval to surgery and better visual outcomes were significantly associated with fewer defects within the ORL at 6 months. These findings suggest that earlier surgery may limit RRD-associated photoreceptor degeneration and improve the patient’s visual prognosis.