RT Journal Article
SR Electronic
T1 Effects of image brightness and contrast dynamic altering stimuli (DAS) when viewing video content on ocular blood flow
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1511
OP 1517
DO 10.1136/bjophthalmol-2018-312561
VO 103
IS 10
A1 Brent Siesky
A1 Alon Harris
A1 Joshua Gross
A1 Emma Sechrist
A1 David Camp
A1 Andrea Cardenas
A1 Pooja Patel
A1 Fawaz Hasnain
A1 Rachel Kawiecki
A1 Aaditya Shah
A1 Alice C Verticchio Vercellin
YR 2019
UL http://bjo.bmj.com/content/103/10/1511.abstract
AB Background/Aim Blood flow deficiencies of the retinal and retrobulbar circulations have been previously reported in open-angle glaucoma (OAG) and other eye diseases. Herein we investigated the effects of image brightness and contrast dynamic altering stimuli (DAS) when viewing a video content on ocular blood flow, intraocular pressure (IOP) and ocular perfusion pressure (OPP) in OAG and healthy subjects.Methods Thirty-five subjects, 25 with OAG (mild to moderate) and 10 healthy controls, were evaluated for blood pressure, IOP, OPP and retinal capillary blood flow before, immediately after, 30 min after and 60 min after using ReviView (a dichoptic video goggles device), which stimulates one eye with a DAS video image that is brighter and with greater contrast than the fellow eye (duration of exposure 30 min). Differences between each subject’s eyes and between OAG and healthy subjects were evaluated using repeated-measures analysis of variance with p<0.05 considered statistically significant.Results All subjects demonstrated a significant increase in OPP in both eyes immediately following viewing. In all DAS eyes, retinal capillary blood flow rose immediately after stimulation and remained elevated for an hour postviewing. Viewing DAS increased retinal blood flow compared with control eyes (p=0.0014, 0.0135 superiorly and p=0.0094, 0.0001 inferiorly, at 30 and 60 min, respectively). OAG eyes had a significant reduction in the number of dormant retinal capillaries (p=0.0174), while healthy eyes demonstrated a larger increase in retinal capillary blood flow (p=0.0006 and p=0.0093 at 60 min, superior and inferior, respectively) following DAS viewing.Conclusion Viewing DAS video for 30 min using ReviView increased retina blood flow both in healthy subjects and in patients with OAG.Trial registration number NCT02959593.