PT  - JOURNAL ARTICLE
AU  - Pierre Chauvelot
AU  - Andrea Skanjeti
AU  - Yvan Jamilloux
AU  - Audrey de Parisot
AU  - Christiane Broussolle
AU  - Philippe Denis
AU  - Jean Marie Ramackers
AU  - Francesco Giammarile
AU  - Laurent Kodjikian
AU  - Pascal Seve
TI  - <sup>18</sup>F-fluorodeoxyglucose positron emission tomography is useful for the diagnosis of intraocular sarcoidosis in patients with a normal CT scan
AID  - 10.1136/bjophthalmol-2018-313133
DP  - 2019 Nov 01
TA  - British Journal of Ophthalmology
PG  - 1650--1655
VI  - 103
IP  - 11
4099  - http://bjo.bmj.com/content/103/11/1650.short
4100  - http://bjo.bmj.com/content/103/11/1650.full
SO  - Br J Ophthalmol2019 Nov 01; 103
AB  - Aim To assess the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and the predictive factors for the diagnosis of sarcoidosis in patients with uveitis who have normal thoracic tomography.Methods We retrospectively reviewed 67 consecutive patients with uveitis of unknown aetiology or a suspected sarcoidosis. All patients with normal thoracic tomography underwent an 18F-FDG PET/CT, which was blindly reinterpreted. We then assessed the proportion of positive 18F-FDG PET/CT and the impact on the final aetiology, using Abad’s criteria for the diagnosis of intraocular sarcoidosis.Results 19 of the 67 patients (28.4%) had mediastinal hypermetabolic foci on their 18F-FDG PET/CT consistent with sarcoidosis. It identified a biopsy site in two cases, which were consistent with sarcoidosis. At the end of the study, six patients (10%) had a proven sarcoidosis, six patients (9%) were considered as having a presumed sarcoidosis and 18 patients (26.9%) as having indeterminate sarcoidosis. 18F-FDG PET/CT enabled the diagnosis of presumed sarcoidosis in these six patients. An older age at diagnosis (p=0.004) and the presence of synechiae (p=0.02) were significantly related to an abnormal 18F-FDG PET/CT, with a trend for an elevated ACE (p=0.0993). We established a nomogram to estimate the probability of having positive findings on the 18F-FDG PET/CT according to different predictive factors.Conclusion 18F-FDG PET/CT enabled the diagnosis of intraocular sarcoidosis even in patients with a normal CT scan. Older age at diagnosis, presence of synechiae and elevated ACE are associated with positive findings on 18F-FDG PET/CT consistent with sarcoidosis.