PT  - JOURNAL ARTICLE
AU  - Ramin Salouti
AU  - Mohammad Zamani
AU  - Maryam Ghoreyshi
AU  - Isabel Dapena
AU  - Gerrit R.J. Melles
AU  - Mohammad Hossein Nowroozzadeh
TI  - Comparison between manual trephination versus femtosecond laser-assisted deep anterior lamellar keratoplasty for keratoconus
AID  - 10.1136/bjophthalmol-2018-313365
DP  - 2019 Dec 01
TA  - British Journal of Ophthalmology
PG  - 1716--1723
VI  - 103
IP  - 12
4099  - http://bjo.bmj.com/content/103/12/1716.short
4100  - http://bjo.bmj.com/content/103/12/1716.full
SO  - Br J Ophthalmol2019 Dec 01; 103
AB  - Background/aims To compare the outcomes of femtosecond laser-assisted deep anterior lamellar keratoplasty (F-DALK) versus manual trephination DALK (M-DALK) in patients with keratoconus.Methods In this retrospective, comparative, clinical study, medical charts of 860 patients with keratoconus who underwent F-DALK (n=391) or M-DALK (n=469) with the Melles’s technique, and had at least a 12-month follow-up record were reviewed. The main outcome measures comprised best spectacle-corrected visual acuity (BSCVA), manifest refraction and keratometric indices. The postsurgical measurements were recorded for all patients at 12 months (suture-in condition), and a subset of patients with complete data at 24 months (suture-out condition; 111 F-DALK and 282 M-DALK cases).Results Both procedures had comparable mean (±SD) logMAR BSCVA at 12 months (0.18±0.12 for M-DALK and 0.17±0.12 for F-DALK; p=0.224) and 24 months (0.11±0.10 vs 0.09±0.09, respectively; p=0.166) examinations. M-DALK was associated with a significant more residual myopia at 12 months (−3.85±3.27 vs -1.94±2.86 D; p<0.001), and a milder similar trend at 24 months follow-up (−2.94±2.72 vs −2.38±2.65 D, p=0.064). The mean keratometry (12 months: 46.15±1.88 vs 44.39±1.72, p<0.001; 24 months: 45.33±2.37 vs 44.14±1.68, p<0.001) and apical keratometry values (12 months: 50.92±5.00 vs 47.13±2.38, p<0.001; 24 months: 50.29±4.25 vs 48.12±3.81) were significantly greater for M-DALK than F-DALK, while the keratometric astigmatism was similar (12 months: 2.62±1.58 vs 2.53±1.33, p=0.364; 24 months: 3.21±1.83 vs 3.34±1.88, p=0.529).Conclusions F-DALK for advanced keratoconus performs as well as M-DALK in terms of BSCVA and keratometric astigmatism in both suture-in (12 months) and suture-out (24 months) conditions. It might have advantages over M-DALK for residual myopia and restoring corneal anatomy.