PT  - JOURNAL ARTICLE
AU  - Amaro, David
AU  - Carreño, Ester
AU  - Steeples, Laura R.
AU  - Oliveira-Ramos, Filipa
AU  - Marques-Neves, Carlos
AU  - Leal, Inês
TI  - Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review
AID  - 10.1136/bjophthalmol-2019-314926
DP  - 2020 Jun 01
TA  - British Journal of Ophthalmology
PG  - 742--747
VI  - 104
IP  - 6
4099  - http://bjo.bmj.com/content/104/6/742.short
4100  - http://bjo.bmj.com/content/104/6/742.full
SO  - Br J Ophthalmol2020 Jun 01; 104
AB  - Inflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury and may cause permanent renal impairment. Eye inflammation can manifest in different anatomical forms, most commonly as bilateral anterior uveitis and may progress to a chronic course. TINU syndrome accounts for approximately 1%–2% of uveitis in tertiary referral centres. A literature review covering the clinical features, pathogenesis, diagnosis and treatment is presented.