@article {Ducloyer842, author = {Jean-Baptiste Ducloyer and Angelique Caignard and Ramzi Aidaoui and Yolaine Ollivier and Guillaume Plubeau and Sonia Santos-Moskalyk and Lindsay Porphyre and Caroline Le Jeune and Lionel Bihl and Samy Alamine and Romain Marignier and Romain Bourcier and Mathilde Ducloyer and Michel Weber and Guyl{\`e}ne Le Meur and Sandrine Wiertlewski and Pierre Lebranchu}, title = {MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis}, volume = {104}, number = {6}, pages = {842--845}, year = {2020}, doi = {10.1136/bjophthalmol-2019-314845}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objective What is the proportion of antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab) in optic neuritis (ON) in adults and what would be the ON presentation for which MOG-Ab should be tested?Methods Multicentric prospective study conducted during 1 year on all patients diagnosed with acute ON in all ophthalmological units in hospitals in a region in western France.Results Sixty-five patients were included. MOG-Ab prevalence was 14\% (9/65) during an acute ON and 13\% (7/55) after exclusion of patients already diagnosed with multiple sclerosis (MS) (8) or MOG+ON (2). Compared with MS and clinically isolated syndrome, MOG+ON had no female preponderance (67\% of men in case of MOG+ON and 22\% of men in case of MS and clinically isolated syndrome, p\<0.05) were more often bilateral (44\% vs 3\%, p\<0.005) and associated with optic disc swelling (ODS) (78\% vs 14\%, p\<0.001). To predict MOG+ON, the positive predictive values (PPVs) of male sex, ODS and bilateral involvement were 29\% (95\% CI 9\% to 48\%), 41\% (95\% CI 18\% to 65\%) and 40\% (95\% CI 10\% to 70\%), respectively, while the negative predictive values (NPV) were 93\% (95\% CI 86\% to 100\%), 96\% (95\% CI 90\% to 100\%) and 91\% (95\% CI 83\% to 99\%), respectively. The combined factor {\textquoteleft}ODS or bilateral or recurrent ON{\textquoteright} was the best compromise between PPV (31\% (95\% CI 14\% to 48\%)) and NPV (100\% (95\% CI 100\% to 100\%)).Conclusion Among ON episodes, MOG-Ab were found in 14\% of cases. MOG+ON occurred without female preponderance and was significantly associated with ODS and/or bilateral ON. Testing MOG-Ab only in patients presenting with ODS or bilateral or recurrent ON would limit MOG-Ab tests to fewer than half of all patients without the risk of missing any MOG+ON cases.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/104/6/842}, eprint = {https://bjo.bmj.com/content/104/6/842.full.pdf}, journal = {British Journal of Ophthalmology} }