PT  - JOURNAL ARTICLE
AU  - Rami Darwich
AU  - Feras M Ghazawi
AU  - Elham Rahme
AU  - Nebras Alghazawi
AU  - Andrei Zubarev
AU  - Linda Moreau
AU  - Denis Sasseville
AU  - Miguel N Burnier, Jr
AU  - Ivan V Litvinov
TI  - Epidemiology of ophthalmic lymphoma in Canada during 1992–2010
AID  - 10.1136/bjophthalmol-2019-314653
DP  - 2020 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1176--1180
VI  - 104
IP  - 8
4099  - http://bjo.bmj.com/content/104/8/1176.short
4100  - http://bjo.bmj.com/content/104/8/1176.full
SO  - Br J Ophthalmol2020 Aug 01; 104
AB  - Background Ophthalmic lymphoma (OL) is the most common orbital tumour, particularly in older individuals. Little is known about the epidemiology and geographic distribution of OL in Canada. Descriptive demographic statistics are an important first step in understanding OL burden and are necessary to inform comprehensive national cancer prevention programmes.Methods We determined patterns of incidence and geographical distribution of the three major subtypes of OL: extranodal marginal zone B cell lymphoma, follicular lymphoma (FL) and diffuse large B cell lymphoma. Here, we used cases that were diagnosed during 1992–2010 using two independent population-based cancer registries, the Canadian Cancer Registry and Le Registre Québécois du Cancer (LRQC).Results The OL mean annual age-standardised incidence rate for 1992–2010 was 0.65 cases per million people per year with an average annual increase in the incidence rate of 4.5% per year. The mean age of diagnosis was 65 years. OL incidence rate was the highest in the cities located along the heavily industrialised Strait of Georgia in British Columbia.Conclusions Our data on patient age, sex and temporal trends showed similarities with data reported in the USA and Denmark. Additional studies are needed to determine whether the observed increase in OL incidence is genuine or spurious.