%0 Journal Article %A Pierre-jean Bertrand %A Yvan Jamilloux %A Laurent Kodjikian %A Marie-Helene Errera %A Laurent Perard %A Gregory Pugnet %A Nathalie Tieulie %A Marc Andre %A Philip Bielefeld %A Alain M Bron %A Evelyne Decullier %A Sylvie Bin %A Pascal Seve %T Quality of life in patients with uveitis: data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis) %D 2020 %R 10.1136/bjophthalmol-2020-315862 %J British Journal of Ophthalmology %P bjophthalmol-2020-315862 %X Aims To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up.Methods Non-inferiority, prospective, multicentre, cluster randomised controlled trial registered under the Unique Identifier: NCT01162070. VR-QOL and HR-QOL were assessed by the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and the Medical Outcomes Study 36-item Short Form Survey (SF-36).Results At inclusion, 466 patients completed the VFQ-25. The mean composite score was 80.0 (±16.7). In multivariate analysis, higher age, female sex and insidious onset were significantly associated with lower QOL. At 6 months, 138 patients completed the VFQ-25, with a significantly higher mean composite score of 82.6 (±16.7). SF-36 mental component was 42.9 (±11.3) and physical component was 47.2 (±8.5) at inclusion (n=425). HR-QOL improvement at 6 months was not clinically significant.Conclusion QOL seems relatively well preserved in this cohort; only VR-QOL improved significantly at 6 months, especially in patients with low initial visual acuity. %U https://bjo.bmj.com/content/bjophthalmol/early/2020/07/24/bjophthalmol-2020-315862.full.pdf