RT Journal Article
SR Electronic
T1 Quality of life in patients with uveitis: data from the ULISSE study (Uveitis: cLInical and medico-economic evaluation of a Standardised Strategy for the Etiological diagnosis)
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2020-315862
DO 10.1136/bjophthalmol-2020-315862
A1 Pierre-jean Bertrand
A1 Yvan Jamilloux
A1 Laurent Kodjikian
A1 Marie-Helene Errera
A1 Laurent Perard
A1 Gregory Pugnet
A1 Nathalie Tieulie
A1 Marc Andre
A1 Philip Bielefeld
A1 Alain M Bron
A1 Evelyne Decullier
A1 Sylvie Bin
A1 Pascal Seve
YR 2020
UL http://bjo.bmj.com/content/early/2020/07/24/bjophthalmol-2020-315862.abstract
AB Aims To assess vision-related (VR-QOL) and health-related quality of life (HR-QOL) in a large series of patients with de novo uveitis at baseline and 6-month follow-up.Methods Non-inferiority, prospective, multicentre, cluster randomised controlled trial registered under the Unique Identifier: NCT01162070. VR-QOL and HR-QOL were assessed by the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and the Medical Outcomes Study 36-item Short Form Survey (SF-36).Results At inclusion, 466 patients completed the VFQ-25. The mean composite score was 80.0 (±16.7). In multivariate analysis, higher age, female sex and insidious onset were significantly associated with lower QOL. At 6 months, 138 patients completed the VFQ-25, with a significantly higher mean composite score of 82.6 (±16.7). SF-36 mental component was 42.9 (±11.3) and physical component was 47.2 (±8.5) at inclusion (n=425). HR-QOL improvement at 6 months was not clinically significant.Conclusion QOL seems relatively well preserved in this cohort; only VR-QOL improved significantly at 6 months, especially in patients with low initial visual acuity.