PT  - JOURNAL ARTICLE
AU  - Vinod Kumar
AU  - Devashish Dubey
AU  - Devesh Kumawat
AU  - Ashish Markan
AU  - Parijat Chandra
AU  - Mahesh Chandra
AU  - Atul Kumar
TI  - Role of internal limiting membrane peeling in the prevention of epiretinal membrane formation following vitrectomy for retinal detachment: a randomised trial
AID  - 10.1136/bjophthalmol-2019-315095
DP  - 2020 Sep 01
TA  - British Journal of Ophthalmology
PG  - 1271--1276
VI  - 104
IP  - 9
4099  - http://bjo.bmj.com/content/104/9/1271.short
4100  - http://bjo.bmj.com/content/104/9/1271.full
SO  - Br J Ophthalmol2020 Sep 01; 104
AB  - Aim To study the role of internal limiting membrane (ILM) peeling in the prevention of macular epiretinal membrane (ERM) formation following pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD).Methods In a randomised trial, patients with macula-off RRD (duration ≤3 months) with proliferative vitreoretinopathy grade ≤C1 and absence of pre-existing maculopathy were recruited from June 2016 to May 2018. Patients were randomised into two groups: group 1 (conventional treatment) underwent PPV alone, while group 2 underwent PPV with macular ILM peeling. The main outcome measures were macular ERM formation (detected on optical coherence tomography), corrected distance visual acuity (CDVA), retinal attachment and central macular thickness (CMT) at last follow-up (minimum 6 months).Results Sixty patients (30 in each group) completed the required follow-up. The two groups were comparable in sex distribution, age, duration of RRD, baseline CDVA and duration of follow-up (median 15.5 vs 14 months). Macular ERM developed in 20% (n=6) and 0% of eyes in groups 1 and 2, respectively (p=0.002). Retinal reattachment was attained in all eyes. There was no statistical difference in final CDVA between the groups (p=0.43). Dissociated optic nerve fibre layer (DONFL) was found in 0% and 40% (n=12) of eyes in groups 1 and 2, respectively (p=0.0001). However, DONFL did not significantly affect the final CDVA (p=0.84). The final CMT was 266.0±37.5 µm and 270.0±73.7 µm in groups 1 and 2, respectively, with no statistical difference (p=0.62).Conclusions ILM peeling prevents macular ERM formation following PPV for RRD but provides similar visual outcomes as compared with conventional treatment.Trial registration number CTRI2018/04/012978.