PT  - JOURNAL ARTICLE
AU  - Jennifer R Evans
AU  - Samantha R de Silva
AU  - Mohammed Ziaei
AU  - Varo Kirthi
AU  - Martin D Leyland
TI  - Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set
AID  - 10.1136/bjophthalmol-2019-315410
DP  - 2020 Oct 01
TA  - British Journal of Ophthalmology
PG  - 1345--1349
VI  - 104
IP  - 10
4099  - http://bjo.bmj.com/content/104/10/1345.short
4100  - http://bjo.bmj.com/content/104/10/1345.full
SO  - Br J Ophthalmol2020 Oct 01; 104
AB  - Background/aims To describe and summarise the outcomes reported in randomised controlled trials of multifocal versus monofocal intraocular lenses in cataract surgery.Methods We identified all randomised controlled trials of multifocal versus monofocal lenses in a Cochrane review (last search date June 2016). We extracted and summarised data on all outcomes reported using the framework of domain, measurement, metric and method of aggregation.Results All studies collected data on distance and near visual acuity but there was considerable variation in the measures used and whether these outcomes were unaided or best corrected. Most studies reported final value measurements, rather than change from baseline. Approximately half of the studies reported data as a continuous measure only, one-third reported both continuous and categorical measures and a minority reported categorical measures only. There was little consensus as to cut-points. Although a majority of studies included one or more patient-reported outcome measures, none of the studies reported patient involvement in the choice of outcomes.Conclusion The collection and analysis of data on outcome measures in studies of multifocal intraocular lenses in cataract surgery are complicated. As a result, there is considerable heterogeneity in collection and reporting in the medical literature. This makes it difficult to synthesise such data to provide robust estimates of effect and is a potential source of research waste. Investigators in this field must produce a core outcome set that is informed by patients’ views and we propose an initial set of outcomes on which these could be based.