RT Journal Article
SR Electronic
T1 Time trends, associations and global burden of intraocular foreign bodies
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2020-317063
DO 10.1136/bjophthalmol-2020-317063
A1 Guangming Jin
A1 Minjie Zou
A1 Yichi Zhang
A1 Aiming Chen
A1 Charlotte Aimee Young
A1 Yi Li
A1 Ling Jin
A1 Nathan Congdon
A1 Danying Zheng
YR 2020
UL http://bjo.bmj.com/content/early/2020/11/25/bjophthalmol-2020-317063.abstract
AB Purpose To estimate the disease burden due to intraocular foreign bodies (IOFBs) and evaluate contributions of various risk factors to IOFB-associated disability-adjusted life-years (DALYs).Methods Global, regional and country-level number, rate and age-standardised rate of DALYs due to IOFBs were acquired from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI) and other region and country-level data were obtained from open databases. Time trends for number, rate and age-standardised rate of DALYs due to IOFBs were calculated. Regression analysis was used to evaluate associations between age-standardised rate of DALYs and potential predictors.Results Global DALYs due to IOFBs rose by 43.7% between 1990 (139 (95% CI 70.8 to 233) thousand) and 2017 (202 (95% CI 105 to 335) thousand). The DALY rate remained stable while the age-standardised rate decreased during this period. Higher disease burden due to IOFBs was associated with higher glaucoma prevalence (β=0.006, 95% CI 0.003 to 0.09, p<0.001), lower refractive error prevalence (β=−0.0005, 95% CI −0.0007 to −0.0002, p<0.001), and lower income (β=−0.020, 95% CI −0.035 to −0.006, p=0.007).Conclusion Predictors of a greater burden of IOFB disability generally point to lower socioeconomic level. The association with glaucoma may reflect a complication of IOFB, increasing risk of vision loss and disability.