PT  - JOURNAL ARTICLE
AU  - Zhi Da Soh
AU  - Sahil Thakur
AU  - Shivani Majithia
AU  - Monisha Esther Nongpiur
AU  - Ching-Yu Cheng
TI  - Iris and its relevance to angle closure disease: a review
AID  - 10.1136/bjophthalmol-2020-316075
DP  - 2021 Jan 01
TA  - British Journal of Ophthalmology
PG  - 3--8
VI  - 105
IP  - 1
4099  - http://bjo.bmj.com/content/105/1/3.short
4100  - http://bjo.bmj.com/content/105/1/3.full
SO  - Br J Ophthalmol2021 Jan 01; 105
AB  - Glaucoma is a leading cause of irreversible visual impairment, and primary angle closure glaucoma (PACG) affects Asians disproportionately. Whereas advances in ocular imaging have identified several anatomical risk factors, our ability to predict PACG still requires considerable improvement. The iris plays a crucial role in the pathophysiology of angle closure disease, either through a mechanical or vascular mechanism. Irises of closed-angle eyes inhibit vastly different structural constituents as compared with those of open-angle eyes, thereby effecting variations in biomechanical properties and iris fluid conductivity. The clinical consequences include a smaller change in iris volume on pupil dilation in closed-angle eyes, thereby bringing the iris and trabecular meshwork closer in apposition. In this review, we summarise the potential role of the iris in the pathogenesis of angle closure disease.