RT Journal Article
SR Electronic
T1 Iris and its relevance to angle closure disease: a review
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 3
OP 8
DO 10.1136/bjophthalmol-2020-316075
VO 105
IS 1
A1 Zhi Da Soh
A1 Sahil Thakur
A1 Shivani Majithia
A1 Monisha Esther Nongpiur
A1 Ching-Yu Cheng
YR 2021
UL http://bjo.bmj.com/content/105/1/3.abstract
AB Glaucoma is a leading cause of irreversible visual impairment, and primary angle closure glaucoma (PACG) affects Asians disproportionately. Whereas advances in ocular imaging have identified several anatomical risk factors, our ability to predict PACG still requires considerable improvement. The iris plays a crucial role in the pathophysiology of angle closure disease, either through a mechanical or vascular mechanism. Irises of closed-angle eyes inhibit vastly different structural constituents as compared with those of open-angle eyes, thereby effecting variations in biomechanical properties and iris fluid conductivity. The clinical consequences include a smaller change in iris volume on pupil dilation in closed-angle eyes, thereby bringing the iris and trabecular meshwork closer in apposition. In this review, we summarise the potential role of the iris in the pathogenesis of angle closure disease.