RT Journal Article
SR Electronic
T1 Central serous chorioretinopathy imaging biomarkers
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2020-317422
DO 10.1136/bjophthalmol-2020-317422
A1 Sumit Randhir Singh
A1 Claudio Iovino
A1 Dinah Zur
A1 Dua Masarwa
A1 Matias Iglicki
A1 Ramkailash Gujar
A1 Marco Lupidi
A1 Dmitrii S Maltsev
A1 Elodie Bousquet
A1 Mehdi Bencheqroun
A1 Francesca Amoroso
A1 Luiz H Lima
A1 Srikanta Kumar Padhy
A1 Vishal Govindahari
A1 Khushboo Chandra
A1 Eric H Souied
A1 Francisco J Rodriguez
A1 Laura A Daza
A1 Hernan A Rios
A1 Carlo Cagini
A1 Enrico Peiretti
A1 Francine Behar-Cohen
A1 Jay Chhablani
YR 2020
UL http://bjo.bmj.com/content/early/2020/12/14/bjophthalmol-2020-317422.abstract
AB Purpose To identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months.Methods Patients with diagnosis of CSCR, either acute or chronic, were included in this multicentric, retrospective study. Demographic factors; systemic risk factors; central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ) and interdigitation zone damage on optical coherence tomography; details of leak on fluorescein angiography and indocyanine green angiography were included as predictors of anatomical and visual outcomes. Regression analysis was performed to correlate the changes in best corrected visual acuity (BCVA) and resolution of disease activity.Results A total of 231 eyes of 201 patients with a mean age (49.7±11.8 years) were analysed. A total of 97 and 134 eyes were classified as acute and chronic CSCR. BCVA (0.35±0.31 to 0.24±0.34; p<0.001), baseline optical coherence tomography (OCT) parameters including CMT (p<0.001), subretinal fluid (SRF) height (p<0.001) and SFCT (p=0.05) showed a significant change through 12 months. Multivariate regression analysis showed change in CMT (p≤0.01) and SRF height at baseline (p=0.05) as factors predictive of good visual outcome. Logistic regression analysis revealed changes in both CMT (p=0.009) and SFCT (p=0.01) through 12 months to correlate with the resolution of disease.Conclusion OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in CMT and baseline SRF height correlate well with changes in BCVA through 12 months.