PT - JOURNAL ARTICLE AU - Anita Lai-Wah Li AU - Sophia Ling Li AU - Ka Wai Kam AU - Alvin Lerrmann Young TI - Randomised assessor<strong>-</strong>masked trial evaluating topical manuka honey (Optimel) in treatment of meibomian gland dysfunction AID - 10.1136/bjophthalmol-2020-317506 DP - 2021 Jan 08 TA - British Journal of Ophthalmology PG - bjophthalmol-2020-317506 4099 - http://bjo.bmj.com/content/early/2021/01/08/bjophthalmol-2020-317506.short 4100 - http://bjo.bmj.com/content/early/2021/01/08/bjophthalmol-2020-317506.full AB - Purpose To evaluate the effects of manuka honey eye-drops in the treatment of meibomian gland dysfunction.Methods This is an assessor-masked (single-blind), randomised controlled trial comparing conventional treatment group with interventional group using Optimel 16% manuka honey topical eye-drops. 59 patients were recruited to the study and randomised into two groups: one given regular lubricants and the other given Optimel 16% manuka honey eye-drops. The Standard Patient Evaluation of Eye Dryness (SPEED) score was measured at baseline and on follow-up. 4 patients were lost to follow-up. Multiple ocular surface parameters were graded from slit lamp examination by a masked assessor. Results were compared from baseline to follow-up date 3 weeks later.Results Patients in the conventional treatment group demonstrated minimal difference in SPEED score at 3-week follow-up (mean difference 1.087, p=0.183), which was not statistically significant. However, measurements of tear film break-up time, corneal surface stain (Oxford), lid margin, conjunctival redness, as well as meibum quality and expressibility showed significant improvements at 3 weeks (p&lt;0.01). Patients in the manuka honey eye-drops group showed significant difference after 3 weeks in SPEED score (mean difference 2.53, p=0.006), as well as in lid margin redness, conjunctival redness, corneal surface stain (Oxford), and meibum quality and expressibility (p=0.000).Conclusions Optimel 16% manuka honey eye-drops showed significant improvement in symptoms and objective signs in meibomian gland dysfunction and are an effective alternative treatment for meibomian gland dysfunction.Trial registration number NCT04457648.