TY - JOUR T1 - Correlation of ocular rigidity with intraocular pressure spike after intravitreal injection of bevacizumab in exudative retinal disease JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 392 LP - 396 DO - 10.1136/bjophthalmol-2019-315595 VL - 105 IS - 3 AU - Diane N Sayah AU - Andrei-Alexandru Szigiato AU - Javier Mazzaferri AU - Denise Descovich AU - Renaud Duval AU - Flavio A Rezende AU - Santiago Costantino AU - Mark R Lesk Y1 - 2021/03/01 UR - http://bjo.bmj.com/content/105/3/392.abstract N2 - Background/aims To evaluate the non-invasive measurement of ocular rigidity (OR), an important biomechanical property of the eye, as a predictor of intraocular pressure (IOP) elevation after anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI).Methods Subjects requiring IVI of anti-VEGF for a pre-existing retinal condition were enrolled in this prospective cross-sectional study. OR was assessed in 18 eyes of 18 participants by measurement of pulsatile choroidal volume change using video-rate optical coherence tomography, and pulsatile IOP change using dynamic contour tonometry. IOP was measured using Tono-Pen XL before and immediately following the injection and was correlated with OR.Results The average increase in IOP following IVI was 19±9 mm Hg, with a range of 7–33 mm Hg. The Spearman correlation coefficient between OR and IOP elevation following IVI was 0.796 (p<0.001), showing higher IOP elevation in more rigid eyes. A regression line was also calculated to predict the IOP spike based on the OR coefficient, such that IOP spike=664.17 mm Hg·µL×OR + 4.59 mm Hg.Conclusion This study shows a strong positive correlation between OR and acute IOP elevation following IVI. These findings indicate that the non-invasive measurement of OR could be an effective tool in identifying patients at risk of IOP spikes following IVI. ER -