RT Journal Article
SR Electronic
T1 Albuminuria and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study (SCES)
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 669
OP 673
DO 10.1136/bjophthalmol-2020-315920
VO 105
IS 5
A1 Zhi Wei Lim
A1 Miao-Li Chee
A1 Sahil Thakur
A1 Xiaoling Fang
A1 Zhi Da Soh
A1 Shivani Majithia
A1 Zhen Ling Teo
A1 Charumathi Sabanayagam
A1 Tien Yin Wong
A1 Ching-Yu Cheng
A1 Yih-Chung Tham
YR 2021
UL http://bjo.bmj.com/content/105/5/669.abstract
AB Aims To determine the association between albuminuria and primary open-angle glaucoma (POAG).Methods Participants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on random spot urinary albumin and creatinine measurements. POAG was defined using the International Society of Geographic and Epidemiological Ophthalmology classification. Multivariable logistic regression with generalised estimating equation model was used to evaluate the association between albuminuria and POAG, while accounting for correlation between eyes.Results A total of 3009 Chinese adults (5963 eyes), aged 40–80 years, were included in this study, of which, 52 subjects (75 eyes) had POAG. Higher UACR (per 50 mg/g increase) was independently associated with POAG (OR=1.04, 95% CI 1.01 to 1.07, p=0.003) following adjustment for age, gender, intraocular pressure, diabetes mellitus, hyperlipidaemia, hypertension, anti-hypertensive medication, history of cardiovascular disease, current smoking status, alcohol intake, body mass index and estimated glomerular filtration rate. Further stratification revealed that individuals with macroalbuminuria were 8.00 times likely to have POAG (95% CI 2.97 to 21.54, p<0.001), compared with those with normoalbuminuria. Microalbuminuria was not significantly associated with POAG (OR=0.49, 95% CI 0.19 to 1.29, p=0.150). The association between macroalbuminuria and POAG remained significant among individuals who were diabetic (OR=9.89, 95% CI 2.49 to 39.30, p=0.001) and hypertensive (OR=8.39, 95% CI 3.07 to 22.94, p<0.001).Conclusion In this population-based study of Chinese adults, albuminuria was independently associated with POAG. Our findings provide further understanding on the pathogenesis of POAG and may potentially help to better identify individuals at risk of POAG.