PT  - JOURNAL ARTICLE
AU  - Shiqi Xie
AU  - Ran Du
AU  - Yuxin Fang
AU  - Yuka Onishi
AU  - Tae Igarashi
AU  - Hiroyuki Takahashi
AU  - Koju Kamoi
AU  - Kyoko Ohno-Matsui
TI  - Dilated choroidal veins and their role in recurrences of myopic macular neovascularisations
AID  - 10.1136/bjophthalmol-2021-318970
DP  - 2021 Apr 28
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2021-318970
4099  - http://bjo.bmj.com/content/early/2021/04/27/bjophthalmol-2021-318970.short
4100  - http://bjo.bmj.com/content/early/2021/04/27/bjophthalmol-2021-318970.full
AB  - Aim To determine whether there is a correlation between the presence of macular dilated choroidal vein (DCV) and the recurrence of myopic macular neovascularisation (MNV) after antivascular endothelial growth factor (VEGF) treatment.Methods Medical records of 168 eyes of 163 patients with myopic MNV were reviewed for the presence of macular DCV and episodes of recurrences. A macular DCV was defined as a choroidal vein whose diameter was 2× larger than the adjacent veins coursing in the macular area of 5.5 mm diameter.Results Macular DCV existed in 47 (28%) of the eyes with myopic MNV. 70 eyes (41.7%) had recurrence during a mean follow-up period of 52.5±23.0 months. Recurrence was found in 28 of the 47 eyes (59.6%) with DCV, which was significantly more frequent than the 42 of the 121 eyes (34.7%) without DCV (p=0.003). Cox model analysis showed that macular DCV was an independent risk factor (HR: 2.0, 95% CI 1.1 to 3.5) for recurrence. The recurrence rate was significantly higher in eyes with DCV within the first 2 years after the onset than in eyes without DCV.Conclusions Macular DCVs may be indicators of a more aggressive phenotype of eyes with myopic MNV. These eyes need careful monitoring after anti-VEGF therapies.Data are available upon reasonable request. Our data are patient image data and this study was approved by the Ethics Committee of Tokyo Medical and Dental University. Data can be available if applying for the permission from Ethics Committee upon reasonable request. Contact address: Ophthalmology & Visual Science Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan 113-8510 TEL 03-3813-6111 FAX 03-3818-7188.