@article {Mendez-Hernandez957, author = {Carmen Mendez-Hernandez, MDPhD and Surina Wang MD and Paula Arribas-Pardo, MDPhD and Liseth Salazar-Qui{\~n}ones MD and Noemi G{\"u}emes-Villahoz MD and Cristina Fernandez-Perez, MDPhD and Julian Garcia-Feijoo, MDPhD}, title = {Diagnostic validity of optic nerve head colorimetric assessment and optical coherence tomography angiography in patients with glaucoma}, volume = {105}, number = {7}, pages = {957--963}, year = {2021}, doi = {10.1136/bjophthalmol-2020-316455}, publisher = {BMJ Publishing Group Ltd}, abstract = {Background/Aims The aim of this study was to assess the optic nerve head (ONH) and macular vessel density with optical coherence tomography angiography (OCT-A) and the ONH haemoglobin (ONH Hb) amount with Laguna ONhE program in open-angle glaucoma (OAG) patients.Methods In this prospective observational cross-sectional study, 67 OAG patients and 41 healthy age-sex frequency matched subjects were examined with OCT-A and retinal photos. The circumpapillary (wcpVD), optic nerve head (iVD) and macular (wmVD) capillary vessel density of OCT-A and ONH colorimetric assessment to determine the ONH Hb amount using the Laguna ONhE program were evaluated.Results Significant differences between normal subjects and glaucoma patients in the wcpVD (22.18{\textpm}3.42 vs 16.03{\textpm}2.89\%; p\<0.001), iVD (18.31{\textpm}5.56 vs 12.52{\textpm}4.67\%; p\<0.001), wmVD (15.60{\textpm}2.34 vs 13.34{\textpm}2.32\%; p\<0.001) and amount of ONH Hb (71.10{\textpm}1.67 vs 68.86{\textpm}2.46\%; p\<0.001) and in the papillary cup (68.14{\textpm}5.25 vs 64.77{\textpm}5.08\%; p=0.001) were found. The Laguna ONhE glaucoma discriminant function (GDF) index had a negative value in the OAG patients and normal values in healthy subjects (-18.76{\textpm}13.31 vs 7.98{\textpm}14.09; p\<0.001). The area under the receiver operating characteristic (ROC) curve (AUROC) for discriminating between healthy and glaucomatous eyes was highest for wcpVD (0.93; 95\% CI 0.86 to 0.97, p\<0.0001), followed by GDF (0.92; 95\% CI 0.86 to 0.97, p\<0.0001), iVD (0.79; 95\% CI 0.70 to 0.86; p\<0.0001) and ONH Hb (0.78; 95\% CI 0.69 to 0.85, p\<0.0001). Pair wise comparisons showed that the AUROC of wcpVD (0.93) was not significantly different than GDF (0.92) (p=0.855).Conclusion Laguna ONhE program and OCT-A have similar diagnostic validity in open-angle glaucoma patients.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/105/7/957}, eprint = {https://bjo.bmj.com/content/105/7/957.full.pdf}, journal = {British Journal of Ophthalmology} }