PT  - JOURNAL ARTICLE
AU  - Mingui Kong
AU  - Sungsoon Hwang
AU  - Hyeonyoung Ko
AU  - Ga-In Lee
AU  - Moonil Kang
AU  - Joohon Sung
AU  - Yun-Mi Song
AU  - Don-Il Ham
TI  - Heritability of macular ganglion cell inner plexiform layer thickness as determined by optical coherence tomography: the Healthy Twin Study
AID  - 10.1136/bjophthalmol-2020-316512
DP  - 2021 Jul 01
TA  - British Journal of Ophthalmology
PG  - 1011--1015
VI  - 105
IP  - 7
4099  - http://bjo.bmj.com/content/105/7/1011.short
4100  - http://bjo.bmj.com/content/105/7/1011.full
SO  - Br J Ophthalmol2021 Jul 01; 105
AB  - Purpose To evaluate genetic influence on macular ganglion cell inner plexiform layer (GCIPL) thickness.Methods Macular GCIPL thickness was measured with optical coherence tomography in nine macular subfields defined by the E TDRS. Intraclass correlation coefficients (ICC) of GCIPL thickness by different types of family relationships were estimated to assess intrafamilial resemblance. Then, heritability of GCIPL thickness was estimated.Results Three hundred and sixty-one Korean adults from 89 families with normal healthy eyes were included. GCIPL thickness was highest in inner subfields and lowest in fovea. Monozygotic twin pairs showed significantly higher ICCs of GCIPL thickness in all subfields compared to those in parent–offspring pairs and sibling pairs. GCIPL thickness was highly heritable in the centre (0.71) and outer subfields but moderate to highly heritable in inner subfields. Heritability of GCIPL thickness in outer subfields was 0.69, 0.67, 0.72 and 0.68 for superior, inferior, temporal and nasal fields, respectively. Heritability of GCIPL thickness in inner subfields was 0.55, 0.56, 0.75 and 050 for superior, inferior, temporal and nasal subfields, respectively.Conclusion Macular GCIPL thickness is significantly influenced by genetic factors. It varies according to subfields with moderate to high heritability in all subfields.