RT Journal Article
SR Electronic
T1 Prevalence and predictors of myopic macular degeneration among Asian adults: pooled analysis from the Asian Eye Epidemiology Consortium
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1140
OP 1148
DO 10.1136/bjophthalmol-2020-316648
VO 105
IS 8
A1 Wong, Yee Ling
A1 Zhu, Xiangjia
A1 Tham, Yih Chung
A1 Yam, Jason C S
A1 Zhang, Keke
A1 Sabanayagam, Charumathi
A1 Lanca, Carla
A1 Zhang, Xiujuan
A1 Han, So Young
A1 He, Wenwen
A1 Susvar, Pradeep
A1 Trivedi, Mihir
A1 Yuan, Nan
A1 Lambat, Sarang
A1 Raman, Rajiv
A1 Song, Su Jeong
A1 Wang, Ya Xing
A1 Bikbov, Mukharram M
A1 Nangia, Vinay
A1 Chen, Li Jia
A1 Wong, Tien Yin
A1 Lamoureux, Ecosse Luc
A1 Pang, Chi-Pui
A1 Cheng, Ching Yu
A1 Lu, Yi
A1 Jonas, Jost B
A1 Saw, Seang Mei
A1 ,
YR 2021
UL http://bjo.bmj.com/content/105/8/1140.abstract
AB Aims To determine the prevalence and predictors of myopic macular degeneration (MMD) in a consortium of Asian studies.Methods Individual-level data from 19 885 participants from four population-based studies, and 1379 highly myopic participants (defined as axial length (AL) >26.0 mm) from three clinic-based/school-based studies of the Asian Eye Epidemiology Consortium were pooled. MMD was graded from fundus photographs following the meta-analysis for pathologic myopia classification and defined as the presence of diffuse choroidal atrophy, patchy chorioretinal atrophy, macular atrophy, with or without ‘plus’ lesion (lacquer crack, choroidal neovascularisation or Fuchs’ spot). Area under the curve (AUC) evaluation for predictors was performed for the population-based studies.Results The prevalence of MMD was 0.4%, 0.5%, 1.5% and 5.2% among Asians in rural India, Beijing, Russia and Singapore, respectively. In the population-based studies, older age (per year; OR=1.13), female (OR=2.0), spherical equivalent (SE; per negative diopter; OR=1.7), longer AL (per mm; OR=3.1) and lower education (OR=1.9) were associated with MMD after multivariable adjustment (all p<0.001). Similarly, in the clinic-based/school-based studies, older age (OR=1.07; p<0.001), female (OR=2.1; p<0.001), longer AL (OR=2.1; p<0.001) and lower education (OR=1.7; p=0.005) were associated with MMD after multivariable adjustment. SE had the highest AUC of 0.92, followed by AL (AUC=0.87). The combination of SE, age, education and gender had a marginally higher AUC (0.94).Conclusion In this pooled analysis of multiple Asian studies, older age, female, lower education, greater myopia severity and longer AL were risk factors of MMD, and myopic SE was the strongest single predictor of MMD.