RT Journal Article SR Electronic T1 Big-data and artificial-intelligence-assisted vault prediction and EVO-ICL size selection for myopia correction JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP bjophthalmol-2021-319618 DO 10.1136/bjophthalmol-2021-319618 A1 Shen, Yang A1 Wang, Lin A1 Jian, Weijun A1 Shang, Jianmin A1 Wang, Xin A1 Ju, Lie A1 Li, Meiyan A1 Zhao, Jing A1 Chen, Xun A1 Ge, Zongyuan A1 Wang, Xiaoying A1 Zhou, Xingtao YR 2021 UL http://bjo.bmj.com/content/early/2021/09/06/bjophthalmol-2021-319618.abstract AB Aims To predict the vault and the EVO-implantable collamer lens (ICL) size by artificial intelligence (AI) and big data analytics.Methods Six thousand two hundred and ninety-seven eyes implanted with an ICL from 3536 patients were included. The vault values were measured by the anterior segment analyzer (Pentacam HR). Permutation importance and Impurity-based feature importance are used to investigate the importance between the vault and input parameters. Regression models and classification models are applied to predict the vault. The ICL size is set as the target of the prediction, and the vault and the other input features are set as the new inputs for the ICL size prediction. Data were collected from 2015 to 2020. Random Forest, Gradient Boosting and XGBoost were demonstrated satisfying accuracy and mean area under the curve (AUC) scores in vault predicting and ICL sizing.Results In the prediction of the vault, the Random Forest has the best results in the regression model (R2=0.315), then follows the Gradient Boosting (R2=0.291) and XGBoost (R2=0.285). The maximum classification accuracy is 0.828 in Random Forest, and the mean AUC is 0.765. The Random Forest predicts the ICL size with an accuracy of 82.2% and the Gradient Boosting and XGBoost, which are also compatible with 81.5% and 81.8% accuracy, respectively.Conclusions Random Forest, Gradient Boosting and XGBoost models are applicable for vault predicting and ICL sizing. AI may assist ophthalmologists in improving ICL surgery safety, designing surgical strategies, and predicting clinical outcomes.Data are available on reasonable request.