PT  - JOURNAL ARTICLE
AU  - David Xu
AU  - Elisha Garg
AU  - Kook Lee
AU  - Yoichi Sakurada
AU  - Atchara Amphornphruet
AU  - Nopasak Phasukkijwatana
AU  - Sandra Liakopoulos
AU  - Scott Eugene Pautler
AU  - Allan E Kreiger
AU  - Suzanne Yzer
AU  - Won Ki Lee
AU  - SriniVas Sadda
AU  - K Bailey Freund
AU  - David Sarraf
TI  - Long-term visual and anatomic outcomes of patients with peripapillary pachychoroid syndrome
AID  - 10.1136/bjophthalmol-2019-315550
DP  - 2020 Dec 20
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2019-315550
4099  - http://bjo.bmj.com/content/early/2021/09/15/bjophthalmol-2019-315550.short
4100  - http://bjo.bmj.com/content/early/2021/09/15/bjophthalmol-2019-315550.full
AB  - Background/Aims To analyse the long-term anatomic and visual outcomes of patients with peripapillary pachychoroid syndrome (PPS), a recently described entity in the pachychoroid disease spectrum.Methods This study retrospectively included patients from several retina centres worldwide. Visual acuity (VA), retinal thickness and choroidal thickness at baseline, 6 months and final follow-up were assessed. Temporal trends in VA and anatomic characteristics were evaluated. Visual and anatomic outcomes in eyes that were observed versus those that were treated were analysed.Results Fifty-six eyes of 35 patients were included with mean follow-up of 27±17 months. Median VA was 20/36 at baseline and remained stable through follow-up (p=0.77). Retinal thickness significantly decreased subfoveally (p=0.012), 1.5 mm nasal to the fovea (p=0.002) and 3.0 mm nasal to the fovea (p=0.0035) corresponding to areas of increased thickening at baseline. Choroidal thickness significantly decreased subfoveally (p=0.0030) and 1.5 mm nasal to the fovea (p=0.0030). Forty-three eyes were treated with modalities including antivascular endothelial growth factor injection, photodynamic therapy, and others. VA remained stable in treated eyes over follow-up (p=0.67). An isolated peripapillary fluid pocket in the outer nuclear layer was characteristic of PPS.Conclusion Patients with PPS experienced decreased retinal oedema and decreased choroidal thickening throughout the course of disease. While some patients experienced visual decline, the overall visual outcome was relatively favourable and independent of trends in retinal or choroidal thickening.Data are available upon reasonable request.