PT - JOURNAL ARTICLE AU - Janice Marie Jordan-Yu AU - Kelvin Teo AU - Qiao Fan AU - Jose Carlos Gana AU - Anna Karina Leopando AU - Sandrina Nunes AU - Cláudia Farinha AU - Patricia Barreto AU - Joana Barbosa Melo AU - Isabel Carreira AU - Joaquim Neto Murta AU - Rufino Silva AU - Chui Ming Gemmy Cheung TI - T and genetic variations between Asian and Caucasian polypoidal choroidal vasculopathy AID - 10.1136/bjophthalmol-2020-317537 DP - 2021 Dec 01 TA - British Journal of Ophthalmology PG - 1716--1723 VI - 105 IP - 12 4099 - http://bjo.bmj.com/content/105/12/1716.short 4100 - http://bjo.bmj.com/content/105/12/1716.full SO - Br J Ophthalmol2021 Dec 01; 105 AB - Purpose To compare phenotypic and genetic variations in polypoidal choroidal vasculopathy (PCV) between Caucasian and Asian patients.Methods We analysed phenotypic and genotypic data from two sites, Association for Innovation and Biomedical Research on Light and Image, Portugal and Singapore National Eye Centre, Singapore. Baseline fundus photography, spectral domain-optical coherence tomography, indocyanine green and fluorescein angiography scans were analysed by respective reading centres using a standardised grading protocol. Single nucleotide polymorphisms across 8 PCV loci were compared between cases and controls selected from each population.Results One hundred and forty treatment-naïve PCV participants (35 Portuguese and 105 Singaporean) were included. The Portuguese cohort were older (72.33±8.44 vs 68.71±9.40 years, p=0.043) and were comprised of a lower proportion of males (43% vs 71%, p=0.005) compared with the Singaporean cohort. Differences in imaging features include higher prevalence of soft drusen (66% vs 30%, p=0.004), lower prevalence of subretinal haemorrhage (14% vs 67%, p<0.001), smaller polypoidal lesion (PL) area (0.09±0.09 vs 0.76±0.93 mm2, p<0.001), lower ratio of PL to branching vascular network area (3% vs 38%, p<0.001) and lower central retinal thickness (346.48±93.74 vs 493.16±212.92 µm, p<0.001) in the Portuguese cohort. CETP rs3764261 (OR 2.467; 95% CI 1.282 to 4.745, p=0.006) in the Portuguese population was significantly associated with PCV and CFH rs800292 (OR 1.719; 95% CI 1.139 to 2.596, p=0.010) in the Singaporean population, respectively.Conclusion Among Asian and Caucasian patients with PCV, there are significant differences in the expression of phenotype. We also identified different polymorphisms associated with PCV in the two populations.