TY - JOUR T1 - Macular and submacular choroidal microvasculature in patients with primary open-angle glaucoma and high myopia JF - British Journal of Ophthalmology JO - Br J Ophthalmol DO - 10.1136/bjophthalmol-2021-319557 SP - bjophthalmol-2021-319557 AU - Fengbin Lin AU - Zhen Qiu AU - Fei Li AU - Yu Chen AU - Yuying Peng AU - Meiling Chen AU - Yunhe Song AU - Jian Xiong AU - Weijing Cheng AU - Yuhong Liu AU - Mingkui Tan AU - Xiulan Zhang AU - Robert Weinreb Y1 - 2021/12/09 UR - http://bjo.bmj.com/content/early/2021/12/09/bjophthalmol-2021-319557.abstract N2 - Aims To characterise the influence of primary open-angle glaucoma (POAG) and high myopia (HM) on the macular and choroidal capillary density (CD).Methods Two hundred and seven eyes were enrolled, including 80 POAG without HM, 50 POAG with HM, 31 HM without POAG and 46 normal controls. A fovea-centred 6×6 mm optical coherence tomography angiography scan was performed to obtain the CD of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris. Macular and choroidal CDs were compared among the groups and the association of CDs with visual field mean deviation (MD) was determined using linear regression models.Results Compared with normal eyes, SCP CD was decreased in the POAG without HM group (p<0.05), while DCP CD was significantly decreased in the HM without POAG group (p<0.05). Both SCP and DCP CDs were significantly decreased in the POAG with HM group (p<0.05). CD reduction occurred mainly in the outer rather than inner ring of the 6×6 mm scan size. In multivariate regression analysis, worse MD was associated with lower CD in the outer ring of the SCP in all the HM eyes (p<0.05).Conclusions POAG and HM reduced macular CD in different layers of the retinal capillary plexus and both particularly in the outer ring of the 6×6 mm scans. Furthermore, assessment of the CD in the outer ring of the SCP may facilitate the diagnosis of glaucoma in eyes with HM.Data are available upon reasonable request. ER -