@article {Lee106, author = {Yung-Sung Lee and Wee-Min Teh and Hsiao-Jung Tseng and Yih-Shiou Hwang and Chi-Chun Lai and Wei-Chi Wu}, title = {Comparison of foveal thickness in preschool children with a history of retinopathy of prematurity and laser photocoagulation or anti-vascular endothelial growth factor treatment: a prospective, longitudinal study}, volume = {106}, number = {1}, pages = {106--112}, year = {2022}, doi = {10.1136/bjophthalmol-2020-317284}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aims To determine longitudinal differences in foveal thickness in preschool-aged patients with or without a history of type I retinopathy of prematurity (ROP).Methods A study of 201 eyes, including 32 laser{\textpm}intravitreal bevacizumab (IVB)-treated eyes, 37 IVB-treated eyes, 14 spontaneously regressed ROP eyes, and 118 age-matched controls were enrolled in this study. The retinal thicknesses (full, inner and outer) were measured in the foveal area at 6-month intervals four consecutive times by optical coherence tomography.Results The foveal thicknesses among the four groups were similar at all four visits (all p\>0.05) after gestational age (GA) adjustment and remained similar with no differences after the full retinal thickness was divided into inner and outer thicknesses (all p\>0.05). The full and outer foveal thicknesses of premature children increased over time (0.17~μm/month and 0.17~μm/month; p=0.0001 and 0.0003, respectively), but the inner foveal thickness remained unchanged with time (0.002~μm/month; p=0.09). Moreover, the positive correlation with best-corrected visual acuity was stronger for outer foveal thickness than for inner foveal thickness (γ=0.281, p\<0.0001 and γ=0.181, p\<0.0001, respectively).Conclusion The thickness of fovea in laser{\textpm}IVB-treated, IVB-treated, regressed ROP and preterm eyes showed no difference after GA adjustment. The whole and outer foveal thicknesses increased with time in preschool-aged children over a 1.5-year follow-up period, but the inner foveal thickness remained unchanged with time.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/106/1/106}, eprint = {https://bjo.bmj.com/content/106/1/106.full.pdf}, journal = {British Journal of Ophthalmology} }