PT  - JOURNAL ARTICLE
AU  - Akshay S Thomas
AU  - Luc Duchateau
AU  - Petra Kozma-Wiebe
AU  - Glenn Jaffe
TI  - Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial
AID  - 10.1136/bjophthalmol-2021-319500
DP  - 2022 Mar 13
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2021-319500
4099  - http://bjo.bmj.com/content/early/2022/03/13/bjophthalmol-2021-319500.short
4100  - http://bjo.bmj.com/content/early/2022/03/13/bjophthalmol-2021-319500.full
AB  - Background/aims To describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular hole (MH) in the Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole study.Methods Phase 3b randomised double-blind sham-controlled multicentre study including 144 eyes with VMT without MH. Eyes were randomised to receive a single intravitreal injection of ocriplasmin or sham injection and were followed for 24 months. Eyes were analysed for presence, course and clinical impact of ELM disruption, EZ disruption and SRF on OCT.Results ELM disruption, EZ disruption and SRF were present in 32.6%, 52.2% and 45.8% of ocriplasmin-treated eyes and 39.6%, 42.6% and 37.5% of sham-treated eyes at baseline. VMT resolution was associated with resolution of ELM and EZ disruption and SRF. A small number of eyes had persistent ELM disruption, EZ disruption and/or SRF at the seventh visit or later (17 months or later) following medical or surgical VMT resolution. Resolution of ELM disruption, EZ disruption and/or SRF was associated with an improvement of visual acuity from baseline. Following VMT resolution, ELM recovery usually preceded EZ recovery and SRF resolution.Conclusions ELM disruption, EZ disruption and/or SRF are present in a significant percentage of eyes with VMT without MH. Release of VMT is usually associated with outer retinal recovery and an associated improvement in visual acuity. ELM recovery typically precedes EZ recovery and SRF resolution following VMT release.No data are available. No data are available for reuse.