RT Journal Article
SR Electronic
T1 Long-term visual and anatomic outcomes of patients with peripapillary pachychoroid syndrome
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 576
OP 581
DO 10.1136/bjophthalmol-2019-315550
VO 106
IS 4
A1 David Xu
A1 Elisha Garg
A1 Kook Lee
A1 Yoichi Sakurada
A1 Atchara Amphornphruet
A1 Nopasak Phasukkijwatana
A1 Sandra Liakopoulos
A1 Scott Eugene Pautler
A1 Allan E Kreiger
A1 Suzanne Yzer
A1 Won Ki Lee
A1 SriniVas Sadda
A1 K Bailey Freund
A1 David Sarraf
YR 2022
UL http://bjo.bmj.com/content/106/4/576.abstract
AB Background/Aims To analyse the long-term anatomic and visual outcomes of patients with peripapillary pachychoroid syndrome (PPS), a recently described entity in the pachychoroid disease spectrum.Methods This study retrospectively included patients from several retina centres worldwide. Visual acuity (VA), retinal thickness and choroidal thickness at baseline, 6 months and final follow-up were assessed. Temporal trends in VA and anatomic characteristics were evaluated. Visual and anatomic outcomes in eyes that were observed versus those that were treated were analysed.Results Fifty-six eyes of 35 patients were included with mean follow-up of 27±17 months. Median VA was 20/36 at baseline and remained stable through follow-up (p=0.77). Retinal thickness significantly decreased subfoveally (p=0.012), 1.5 mm nasal to the fovea (p=0.002) and 3.0 mm nasal to the fovea (p=0.0035) corresponding to areas of increased thickening at baseline. Choroidal thickness significantly decreased subfoveally (p=0.0030) and 1.5 mm nasal to the fovea (p=0.0030). Forty-three eyes were treated with modalities including antivascular endothelial growth factor injection, photodynamic therapy, and others. VA remained stable in treated eyes over follow-up (p=0.67). An isolated peripapillary fluid pocket in the outer nuclear layer was characteristic of PPS.Conclusion Patients with PPS experienced decreased retinal oedema and decreased choroidal thickening throughout the course of disease. While some patients experienced visual decline, the overall visual outcome was relatively favourable and independent of trends in retinal or choroidal thickening.Data are available upon reasonable request.