PT  - JOURNAL ARTICLE
AU  - Edward S Lu
AU  - Ying Cui
AU  - Rongrong Le
AU  - Ying Zhu
AU  - Jay C Wang
AU  - Inês Laíns
AU  - Raviv Katz
AU  - Yifan Lu
AU  - Rebecca Zeng
AU  - Itika Garg
AU  - David M Wu
AU  - Dean Eliott
AU  - Demetrios G Vavvas
AU  - Deeba Husain
AU  - Joan W Miller
AU  - Leo A Kim
AU  - John B Miller
TI  - Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy
AID  - 10.1136/bjophthalmol-2020-317983
DP  - 2022 Apr 01
TA  - British Journal of Ophthalmology
PG  - 534--539
VI  - 106
IP  - 4
4099  - http://bjo.bmj.com/content/106/4/534.short
4100  - http://bjo.bmj.com/content/106/4/534.full
SO  - Br J Ophthalmol2022 Apr 01; 106
AB  - Aims To compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab.Methods A prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included. All patients were imaged with WF SS-OCTA using the 12×12 mm Angio scan protocol centred on the fovea and optic disc. The en-face SS-OCTA VRI Angio slab and SS-OCT VRI Structure slab were evaluated for the presence or absence of NV. SS-OCTA B-scan was used to classify NV according to cross-sectional morphology (forward, tabletop or flat). All statistical analyses were performed using SPSS V.26.0.Results One hundred and forty-two eyes of 89 participants were included in the study. VRI Angio detected NV at higher rates compared with VRI Structure (p<0.05). Combining VRI Angio and Structure improved detection rates compared with VRI Angio alone (p<0.05). Due to segmentation errors of the internal limiting membrane, NV with flat morphological classification had lower rates of detection on VRI Angio compared with NV with forward and tabletop morphology (p<0.05).Conclusions WF SS-OCTA 12×12 mm VRI Angio and SS-OCT VRI Structure imaging centred on the fovea and optic disc detected NV with high sensitivity and low false positives. The VRI slab may be useful to diagnose and monitor PDR in clinical practice.Data are available upon reasonable request. Deidentified participant data used in this study could be shared upon reasonable request sent to the corresponding author.