RT Journal Article
SR Electronic
T1 Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 491
OP 496
DO 10.1136/bjophthalmol-2020-317900
VO 106
IS 4
A1 Wang, Xiaofei
A1 Tun, Tin A
A1 Nongpiur, Monisha Esther
A1 Htoon, Hla M
A1 Tham, Yih Chung
A1 Strouthidis, Nicholas G
A1 Aung, Tin
A1 Cheng, Ching-Yu
A1 Girard, Michael JA
YR 2022
UL http://bjo.bmj.com/content/106/4/491.abstract
AB Aims To compare the shape of the anterior surface of the peripapillary sclera (PPS) between glaucoma and healthy subjects.Methods 88 primary open angle glaucoma (POAG), 98 primary angle closure glaucoma (PACG) and 372 age-matched and gender-matched healthy controls were recruited in this study. The optic nerve head of one randomly selected eye of each subject was imaged with spectral domain optical coherence tomography. The shape of the PPS was measured through an angle defined between a line parallel to the nasal anterior PPS boundary and one parallel to the temporal side. A negative value indicated that the PPS followed an inverted v-shaped configuration (peak pointing towards the vitreous), whereas a positive value indicated that it followed a v-shaped configuration.Results The mean PPS angle in normal controls (4.56±5.99°) was significantly smaller than that in POAG (6.60±6.37°, p=0.011) and PACG (7.90±6.87°, p<0.001). The v-shaped PPS was significantly associated with older age (β=1.79, p<0.001), poorer best-corrected visual acuity (β=3.31, p=0.047), central corneal thickness (β=−0.28, p=0.001), peripapillary choroidal thickness (β=−0.21, p<0.001) and presence of POAG (β=1.94, p<0.009) and PACG (β=2.96, p<0.001). The v-shaped configuration of the PPS significantly increased by 1.46° (p=0.001) in healthy controls for every 10-year increase in age, but not in glaucoma groups.Conclusions The v-shaped configuration of the PPS was more pronounced in glaucoma eyes than in healthy eyes. This posterior bowing of the PPS may have an impact on the biomechanical environment of the optic nerve head.Data are available upon reasonable request. The deidentified participant data were generated at the Singapore Eye Research Institute, Singapore and derived data supporting the findings of this study are available from the corresponding author (MJAG) on request.