PT - JOURNAL ARTICLE AU - Singh, Sumit Randhir AU - Iovino, Claudio AU - Zur, Dinah AU - Masarwa, Dua AU - Iglicki, Matias AU - Gujar, Ramkailash AU - Lupidi, Marco AU - Maltsev, Dmitrii S AU - Bousquet, Elodie AU - Bencheqroun, Mehdi AU - Amoroso, Francesca AU - Lima, Luiz H AU - Padhy, Srikanta Kumar AU - Govindahari, Vishal AU - Chandra, Khushboo AU - Souied, Eric H AU - Rodriguez, Francisco J AU - Daza, Laura A AU - Rios, Hernan A AU - Cagini, Carlo AU - Peiretti, Enrico AU - Behar-Cohen, Francine AU - Chhablani, Jay TI - Central serous chorioretinopathy imaging biomarkers AID - 10.1136/bjophthalmol-2020-317422 DP - 2022 Apr 01 TA - British Journal of Ophthalmology PG - 553--558 VI - 106 IP - 4 4099 - http://bjo.bmj.com/content/106/4/553.short 4100 - http://bjo.bmj.com/content/106/4/553.full SO - Br J Ophthalmol2022 Apr 01; 106 AB - Purpose To identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months.Methods Patients with diagnosis of CSCR, either acute or chronic, were included in this multicentric, retrospective study. Demographic factors; systemic risk factors; central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ) and interdigitation zone damage on optical coherence tomography; details of leak on fluorescein angiography and indocyanine green angiography were included as predictors of anatomical and visual outcomes. Regression analysis was performed to correlate the changes in best corrected visual acuity (BCVA) and resolution of disease activity.Results A total of 231 eyes of 201 patients with a mean age (49.7±11.8 years) were analysed. A total of 97 and 134 eyes were classified as acute and chronic CSCR. BCVA (0.35±0.31 to 0.24±0.34; p<0.001), baseline optical coherence tomography (OCT) parameters including CMT (p<0.001), subretinal fluid (SRF) height (p<0.001) and SFCT (p=0.05) showed a significant change through 12 months. Multivariate regression analysis showed change in CMT (p≤0.01) and SRF height at baseline (p=0.05) as factors predictive of good visual outcome. Logistic regression analysis revealed changes in both CMT (p=0.009) and SFCT (p=0.01) through 12 months to correlate with the resolution of disease.Conclusion OCT parameters such as changes in both CMT and SFCT along with subfoveal EZ damage can be predictive of disease resolution whereas changes in CMT and baseline SRF height correlate well with changes in BCVA through 12 months.Data are available upon reasonable request.