TY - JOUR T1 - OCT-angiography detects longitudinal microvascular changes in glaucoma: a systematic review JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 667 LP - 675 DO - 10.1136/bjophthalmol-2020-318166 VL - 106 IS - 5 AU - Ana Miguel AU - André Silva AU - Joao Barbosa-Breda AU - Luis Azevedo AU - Abdulkarim Abdulrahman AU - Esther Hereth AU - Luis Abegão Pinto AU - Yves Lachkar AU - Ingeborg Stalmans Y1 - 2022/05/01 UR - http://bjo.bmj.com/content/106/5/667.abstract N2 - Background/aims Optical coherence tomography angiography (OCTA) allows the study of vessel density (VD). We intended to perform a systematic review of studies focusing on longitudinal changes in peripapillary and macular VD measurements in glaucoma.Methods A search was performed across MEDLINE, Scopus, ISI Web of Science and Google Scholar, using the following query from inception until 20 September 2019: ((“optical coherence tomography angiography”[tiab]) OR (optical coherence tomography angiography[MeSH]) OR (“OCTA”[tiab]) OR (“OCT-A”[tiab]) OR (“angio-OCT”[tiab]) OR (“OCT- angiography”[tiab]) OR (“OCT-angio”[tiab]) OR (“OCT-angiographie”[tiab])) AND (glaucom*[tiab] OR glaucoma[MeSH]). Prospective studies that quantitatively assessed the longitudinal changes in VD in glaucoma with at least 3 months of follow-up were included.Results Ten out of 4516 studies were included. The rate of VD change in glaucoma varied from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. Five studies assessed VD change after glaucoma surgery, obtaining variable results, ranging from a temporary VD decrease to increase after 3 months. Meta-analysis was not possible due to a wide variation in methods, measurements and region of VD.Conclusion OCTA is a non-invasive technology, which shows promise in glaucoma. Measures should be taken to increase the quality and standardise the methodology of VD measures in OCTA longitudinal studies, for future meta-analyses.Data are available upon reasonable request. Available at request. ER -