RT Journal Article
SR Electronic
T1 Six-year incidence of age-related macular degeneration and correlation to OCT-derived drusen volume measurements in a Chinese population
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2021-319290
DO 10.1136/bjophthalmol-2021-319290
A1 Anna CS Tan
A1 Miao Li Chee
A1 Beau J Fenner
A1 Paul Mitchell
A1 Yih Chung Tham
A1 Tyler Rim
A1 Kelvin Teo
A1 Shaun S Sim
A1 Ching Yu Cheng
A1 Tien Yin Wong
A1 Usha Chakravarthy
A1 Chui Ming Gemmy Cheung
YR 2021
UL http://bjo.bmj.com/content/early/2022/04/20/bjophthalmol-2021-319290.abstract
AB Aims To report the 6-year incidence of optical coherence tomography (OCT)-derived age-related changes in drusen volume and related systemic and ocular associations.Methods Chinese adults aged 40 years and older were assessed at baseline and 6 years with colour fundus photography (CFP) and spectral domain (SD) OCT. CFPs were graded for age-related macular degeneration (AMD) features and drusen volume was generated using commercially available automated software.Results A total of 4172 eyes of 2580 participants (mean age 58.12±9.03 years; 51.12% women) had baseline and 6-year follow-up CFP for grading, of these, 2130 eyes of 1305 participants had gradable SD-OCT images, available for analysis. Based on CFP grading, 136 (3.39%) participants developed incident early AMD and 10 (0.25%) late AMD. Concurrently, retinal pigment epithelial-Bruch’s membrane (RPE-BrC) volumes decreased, remained stable and increased in 6.8%, 78.5% and 14.7%, respectively, over 6 years. In eyes where RPE-BrC volumes were >0 mm3 at baseline, this was associated with two-fold higher prevalence rate of any AMD at baseline (p<0.001). Multivariable analysis showed that when compared with eyes where RPE-BrC volume was unchanged, volume decrease was significantly associated with older age (OR=1.30; p<0.001), smoking (OR=2.21; p=0.001) and chronic kidney disease (OR=3.4, p=0.008), while increase was associated with older age (OR=1.36; p<0.001) and hypertension (OR=1.43; p=0.016).Conclusion AMD incidence detected at 6 years on CFP and correlated OCT-derived drusen volume measurement change is low. Older age and some systemic risk factors are associated with drusen volume change, and our data provide new insights into relationship between systemic risk factors and outer retinal morphology in Asian eyes.All data relevant to the study are included in the article or uploaded as supplementary information. Data is de-identified participant data available from out database not reusable without permission.