TY - JOUR T1 - Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 994 LP - 999 DO - 10.1136/bjophthalmol-2021-319090 VL - 106 IS - 7 AU - Yuichiro Ogura AU - Glenn J Jaffe AU - Chui Ming Gemmy Cheung AU - Gregg T Kokame AU - Tomohiro Iida AU - Kanji Takahashi AU - Won Ki Lee AU - Andrew A Chang AU - Jordi Monés AU - Divya D’Souza AU - Georges Weissgerber AU - Kinfemichael Gedif AU - Adrian Koh Y1 - 2022/07/01 UR - http://bjo.bmj.com/content/106/7/994.abstract N2 - Purpose To compare the efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy (PCV) over 96 weeks in the HAWK study.Design HAWK was a global, 2-year, randomised, double-masked, multicentre phase III trial in participants with neovascular age-related macular degeneration.Methods Of the Japanese participants with PCV, 39 received brolucizumab 6 mg and 30 received aflibercept 2 mg. After 3 monthly loading doses, brolucizumab-treated eyes received an injection every 12 weeks (q12w) but were adjusted to q8w if disease activity was detected. Aflibercept-treated eyes received fixed q8w dosing. Mean change in best-corrected visual acuity (BCVA), the proportion of participants on q12w, retinal thickness, retinal fluid changes and safety were assessed to Week 96.Results Mean change in BCVA (early treatment diabetic retinopathy study (ETDRS) letters) from baseline to week 48/week 96 was+10.4/+11.4 for brolucizumab and +11.6/+11.1 for aflibercept. For brolucizumab-treated eyes, the probability of only q12w dosing after loading through week 48 was 76%, and 68% through week 96. Fluid resolution was greater with brolucizumab than aflibercept: respective proportions of eyes with intraretinal fluid and/or subretinal fluid were 7.7% and 30% at week 48% and 12.8% and 16.7% at week 96. Brolucizumab exhibited an overall well-tolerated safety profile despite a higher rate of intraocular inflammation compared with aflibercept.Conclusion In Japanese eyes with PCV, brolucizumab q12w/q8w monotherapy resulted in robust and consistent BCVA gains that were comparable to q8w aflibercept dosing. Anatomical outcomes favoured brolucizumab over aflibercept, with 76% of brolucizumab participants maintained on q12w dosing after loading to week 48.All data relevant to the study are included in the article or uploaded as supplemental information. All relevant data are included in the manuscript or in the referenced primary manuscript. ER -