RT Journal Article SR Electronic T1 New meaning for NLP: the trials and tribulations of natural language processing with GPT-3 in ophthalmology JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP 889 OP 892 DO 10.1136/bjophthalmol-2022-321141 VO 106 IS 7 A1 Nath, Siddharth A1 Marie, Abdullah A1 Ellershaw, Simon A1 Korot, Edward A1 Keane, Pearse A YR 2022 UL http://bjo.bmj.com/content/106/7/889.abstract AB Natural language processing (NLP) is a subfield of machine intelligence focused on the interaction of human language with computer systems. NLP has recently been discussed in the mainstream media and the literature with the advent of Generative Pre-trained Transformer 3 (GPT-3), a language model capable of producing human-like text. The release of GPT-3 has also sparked renewed interest on the applicability of NLP to contemporary healthcare problems. This article provides an overview of NLP models, with a focus on GPT-3, as well as discussion of applications specific to ophthalmology. We also outline the limitations of GPT-3 and the challenges with its integration into routine ophthalmic care.Data sharing not applicable as no datasets generated and/or analysed for this study.