RT Journal Article
SR Electronic
T1 Impact of incident age-related macular degeneration and associated vision loss on vision-related quality of life
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1063
OP 1068
DO 10.1136/bjophthalmol-2020-318269
VO 106
IS 8
A1 Man, Ryan Eyn Kidd
A1 Gan, Alfred Tau Liang
A1 Fenwick, Eva K
A1 Teo, Kelvin Yi Chong
A1 Tan, Anna C S
A1 Cheung, Gemmy Chui Ming
A1 Teo, Zhen Ling
A1 Kumari, Neelam
A1 Wong, Tien Yin
A1 Cheng, Ching-Yu
A1 Lamoureux, Ecosse Luc
YR 2022
UL http://bjo.bmj.com/content/106/8/1063.abstract
AB Background We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population.Methods Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009–2011; follow-up: 2015–2017), were graded using a modified Wisconsin age-related maculopathy grading system. Incident AMD was defined as no baseline AMD in both eyes and early/late AMD in the worse eye at follow-up. Presenting VA was assessed using the logarithm of the minimum angle of resolution chart at 4 m under standard lighting conditions with habitual correction. Multiple linear regression models determined the associations between AMD incidence with changes in the Rasch-transformed scores of the Reading, Mobility and Emotional VRQoL domains of the 32-item Impact of Visual Impairment (IVI-32) questionnaire, adjusted for traditional confounders. The contribution of presenting VA to changes in VRQoL was also estimated.Results Of the 2251 participants without AMD at baseline (mean age (SD): 57.7 (9) years, 51.4% women), 101 (4.5%) and 11 (0.5%) developed incident early and late AMD at follow-up, respectively. Incident late AMD was associated with significant 30.3%, 32.5% and 30.9% decrements in Reading, Mobility and Emotional IVI scores, respectively. The contribution of presenting VA ranged between 1.62% and 4.35% of the observed decrements. No significant associations were noted with incident early AMD.Conclusion Incident late AMD had a substantial impact on all aspects of VRQoL, with presenting VA contributing only minimally to this longitudinal relationship.Data are available upon reasonable request. Due to Singapore’s strict data sharing law, any data requests will be considered on a case-by-case basis.