PT  - JOURNAL ARTICLE
AU  - Thamanna Nishath
AU  - Xiudi Li
AU  - Arthika Chandramohan
AU  - Megan Othus
AU  - Xunda Ji
AU  - Yihua Zou
AU  - Sadia Sultana
AU  - Riffat Rashid
AU  - Sadik Taju Sherief
AU  - Nathalie Cassoux
AU  - Juan Luis Garcia Leon
AU  - Rosdali Díaz Coronado
AU  - Arturo Manuel Zapata López
AU  - Tatiana L Ushakova
AU  - Vladimir G Polyakov
AU  - Soma Rani Roy
AU  - Alia Ahmad
AU  - Ashwin Reddy
AU  - Mandeep S Sagoo
AU  - Lamis Al Harby
AU  - Jonathan W Kim
AU  - Jesse L Berry
AU  - Ashley Polski
AU  - Nick Astbury
AU  - Cova Bascaran
AU  - Sharon Blum
AU  - Richard Bowman
AU  - Matthew J Burton
AU  - Allen Foster
AU  - Nir Gomel
AU  - Naama Keren-Froim
AU  - Shiran Madgar
AU  - Marcia Zondervan
AU  - Swathi Kaliki
AU  - Ido Didi Fabian
AU  - Andrew Stacey
TI  - Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries
AID  - 10.1136/bjo-2022-321159
DP  - 2022 Sep 16
TA  - British Journal of Ophthalmology
PG  - bjophthalmol-2022-321159
4099  - http://bjo.bmj.com/content/early/2022/09/16/bjo-2022-321159.short
4100  - http://bjo.bmj.com/content/early/2022/09/16/bjo-2022-321159.full
AB  - Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.Results Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).Conclusion Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.Data are available upon reasonable request.