RT Journal Article
SR Electronic
T1 Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2022-321159
DO 10.1136/bjo-2022-321159
A1 Thamanna Nishath
A1 Xiudi Li
A1 Arthika Chandramohan
A1 Megan Othus
A1 Xunda Ji
A1 Yihua Zou
A1 Sadia Sultana
A1 Riffat Rashid
A1 Sadik Taju Sherief
A1 Nathalie Cassoux
A1 Juan Luis Garcia Leon
A1 Rosdali Díaz Coronado
A1 Arturo Manuel Zapata López
A1 Tatiana L Ushakova
A1 Vladimir G Polyakov
A1 Soma Rani Roy
A1 Alia Ahmad
A1 Ashwin Reddy
A1 Mandeep S Sagoo
A1 Lamis Al Harby
A1 Jonathan W Kim
A1 Jesse L Berry
A1 Ashley Polski
A1 Nick Astbury
A1 Cova Bascaran
A1 Sharon Blum
A1 Richard Bowman
A1 Matthew J Burton
A1 Allen Foster
A1 Nir Gomel
A1 Naama Keren-Froim
A1 Shiran Madgar
A1 Marcia Zondervan
A1 Swathi Kaliki
A1 Ido Didi Fabian
A1 Andrew Stacey
YR 2022
UL http://bjo.bmj.com/content/early/2022/09/16/bjo-2022-321159.abstract
AB Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.Results Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).Conclusion Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.Data are available upon reasonable request.