RT Journal Article
SR Electronic
T1 Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2022-321159
DO 10.1136/bjo-2022-321159
A1 Nishath, Thamanna
A1 Li, Xiudi
A1 Chandramohan, Arthika
A1 Othus, Megan
A1 Ji, Xunda
A1 Zou, Yihua
A1 Sultana, Sadia
A1 Rashid, Riffat
A1 Sherief, Sadik Taju
A1 Cassoux, Nathalie
A1 Garcia Leon, Juan Luis
A1 Díaz Coronado, Rosdali
A1 López, Arturo Manuel Zapata
A1 Ushakova, Tatiana L
A1 Polyakov, Vladimir G
A1 Roy, Soma Rani
A1 Ahmad, Alia
A1 Reddy, Ashwin
A1 Sagoo, Mandeep S
A1 Al Harby, Lamis
A1 Kim, Jonathan W
A1 Berry, Jesse L
A1 Polski, Ashley
A1 Astbury, Nick
A1 Bascaran, Cova
A1 Blum, Sharon
A1 Bowman, Richard
A1 Burton, Matthew J
A1 Foster, Allen
A1 Gomel, Nir
A1 Keren-Froim, Naama
A1 Madgar, Shiran
A1 Zondervan, Marcia
A1 Kaliki, Swathi
A1 Fabian, Ido Didi
A1 Stacey, Andrew
YR 2022
UL http://bjo.bmj.com/content/early/2022/09/16/bjo-2022-321159.abstract
AB Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.Results Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).Conclusion Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.Data are available upon reasonable request.