PT  - JOURNAL ARTICLE
AU  - Uwaydat, Sami H
AU  - Mansour, Ahmad
AU  - Ascaso, Francisco J
AU  - Parodi, Maurizio Battaglia
AU  - Foster, Robert
AU  - Smiddy, William E
AU  - Schwartz, Stephen G
AU  - Charbaji, Abdulrazzak
AU  - Belotto, Silvana
AU  - Jürgens, Ignasi
AU  - Mateo, Javier
AU  - Ellabban, Abdallah A
AU  - Wu, Lihteh
AU  - Figueroa, Marta
AU  - Olivier Pascual, Nuria
AU  - Lima, Luiz H
AU  - Alsakran, Wael A
AU  - Caliskan Kadayifcilar, Sibel
AU  - Sinawat, Suthasinee
AU  - Assi, Alexandre
AU  - Mansour, Hana A
AU  - Casella, Antonio Marcello
AU  - Navea, Amparo
AU  - Neila, Elena Rodríguez
AU  - Saatci, A Osman
AU  - Govindahari, Vishal
AU  - Esteban Floria, Olivia
AU  - Agarwal, Komal
AU  - Bakkali El Bakkali, Ismael
AU  - Alaman, Angel Salinas
AU  - Larripa, Sofia Fernandez
AU  - Rey, Amanda
AU  - Pera, Patricia
AU  - Bruix, Lluís
AU  - Lopez-Guajardo, Lorenzo
AU  - Pérez-Salvador, Eduardo
AU  - Lara Medina, Francisco Javier
AU  - Hrisomalos, Frank N
AU  - Chhablani, Jay
AU  - Arevalo, J Fernando
TI  - Clinical characteristics of full thickness macular holes that closed without surgery
AID  - 10.1136/bjophthalmol-2021-319001
DP  - 2022 Oct 01
TA  - British Journal of Ophthalmology
PG  - 1463--1468
VI  - 106
IP  - 10
4099  - http://bjo.bmj.com/content/106/10/1463.short
4100  - http://bjo.bmj.com/content/106/10/1463.full
SO  - Br J Ophthalmol2022 Oct 01; 106
AB  - Purpose To ascertain the anatomic factors that help achieve non-surgical sealing in full thickness macular hole (FTMH).Methods Retrospective collaborative study of FTMH that closed without surgical intervention.Results A total of 78 patients (mean age 57.9 years) included 18 patients with blunt ocular trauma, 18 patients that received topical or intravitreal therapies and 42 patients with idiopathic FTMH. Mean±SD of the initial corrected visual acuity (VA) in logMAR improved from 0.65±0.54 to 0.34±0.45 (p<0.001) at a mean follow-up of 33.8±37.1 months. FTMH reopened in seven eyes (9.0%) after a mean of 8.6 months. Vitreomacular traction was noted in 12 eyes (15.8%), perifoveal posterior vitreous detachment in 42 (53.8%), foveal epiretinal membrane in 10 (12.8%), cystoid macular oedema (CME) in 49 (62.8%) and subretinal fluid (SRF) in 20 (25.6%). By multivariate analysis, initial VA correlated to the height (p<0.001) and narrowest diameter of the hole (p<0.001) while final VA correlated to the basal diameter (p<0.001). Time for closure of FTMH (median 2.8 months) correlated to the narrowest diameter (p<0.001) and the presence of SRF (p=0.001). Mean time for closure (in months) was 1.6 for eyes with trauma, 4.3 for eyes without trauma but with therapy for CME, 4.4 for eyes without trauma and without therapy in less than 200 µm in size and 24.7 for more than 200 µm.Conclusion Our data suggest an observation period in new onset FTMH for non-surgical closure, in the setting of trauma, treatment of CME and size <200 µm.Data are available upon reasonable request. Data are available upon request by email to the corresponding author.