PT  - JOURNAL ARTICLE
AU  - Sami H Uwaydat
AU  - Ahmad Mansour
AU  - Francisco J Ascaso
AU  - Maurizio Battaglia Parodi
AU  - Robert Foster
AU  - William E Smiddy
AU  - Stephen G Schwartz
AU  - Abdulrazzak Charbaji
AU  - Silvana Belotto
AU  - Ignasi Jürgens
AU  - Javier Mateo
AU  - Abdallah A Ellabban
AU  - Lihteh Wu
AU  - Marta Figueroa
AU  - Nuria Olivier Pascual
AU  - Luiz H Lima
AU  - Wael A Alsakran
AU  - Sibel Caliskan Kadayifcilar
AU  - Suthasinee Sinawat
AU  - Alexandre Assi
AU  - Hana A Mansour
AU  - Antonio Marcello Casella
AU  - Amparo Navea
AU  - Elena Rodríguez Neila
AU  - A Osman Saatci
AU  - Vishal Govindahari
AU  - Olivia Esteban Floria
AU  - Komal Agarwal
AU  - Ismael Bakkali El Bakkali
AU  - Angel Salinas Alaman
AU  - Sofia Fernandez Larripa
AU  - Amanda Rey
AU  - Patricia Pera
AU  - Lluís Bruix
AU  - Lorenzo Lopez-Guajardo
AU  - Eduardo Pérez-Salvador
AU  - Francisco Javier Lara Medina
AU  - Frank N Hrisomalos
AU  - Jay Chhablani
AU  - J Fernando Arevalo
TI  - Clinical characteristics of full thickness macular holes that closed without surgery
AID  - 10.1136/bjophthalmol-2021-319001
DP  - 2022 Oct 01
TA  - British Journal of Ophthalmology
PG  - 1463--1468
VI  - 106
IP  - 10
4099  - http://bjo.bmj.com/content/106/10/1463.short
4100  - http://bjo.bmj.com/content/106/10/1463.full
SO  - Br J Ophthalmol2022 Oct 01; 106
AB  - Purpose To ascertain the anatomic factors that help achieve non-surgical sealing in full thickness macular hole (FTMH).Methods Retrospective collaborative study of FTMH that closed without surgical intervention.Results A total of 78 patients (mean age 57.9 years) included 18 patients with blunt ocular trauma, 18 patients that received topical or intravitreal therapies and 42 patients with idiopathic FTMH. Mean±SD of the initial corrected visual acuity (VA) in logMAR improved from 0.65±0.54 to 0.34±0.45 (p<0.001) at a mean follow-up of 33.8±37.1 months. FTMH reopened in seven eyes (9.0%) after a mean of 8.6 months. Vitreomacular traction was noted in 12 eyes (15.8%), perifoveal posterior vitreous detachment in 42 (53.8%), foveal epiretinal membrane in 10 (12.8%), cystoid macular oedema (CME) in 49 (62.8%) and subretinal fluid (SRF) in 20 (25.6%). By multivariate analysis, initial VA correlated to the height (p<0.001) and narrowest diameter of the hole (p<0.001) while final VA correlated to the basal diameter (p<0.001). Time for closure of FTMH (median 2.8 months) correlated to the narrowest diameter (p<0.001) and the presence of SRF (p=0.001). Mean time for closure (in months) was 1.6 for eyes with trauma, 4.3 for eyes without trauma but with therapy for CME, 4.4 for eyes without trauma and without therapy in less than 200 µm in size and 24.7 for more than 200 µm.Conclusion Our data suggest an observation period in new onset FTMH for non-surgical closure, in the setting of trauma, treatment of CME and size <200 µm.Data are available upon reasonable request. Data are available upon request by email to the corresponding author.