RT Journal Article
SR Electronic
T1 Clinical characteristics of full thickness macular holes that closed without surgery
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1463
OP 1468
DO 10.1136/bjophthalmol-2021-319001
VO 106
IS 10
A1 Sami H Uwaydat
A1 Ahmad Mansour
A1 Francisco J Ascaso
A1 Maurizio Battaglia Parodi
A1 Robert Foster
A1 William E Smiddy
A1 Stephen G Schwartz
A1 Abdulrazzak Charbaji
A1 Silvana Belotto
A1 Ignasi Jürgens
A1 Javier Mateo
A1 Abdallah A Ellabban
A1 Lihteh Wu
A1 Marta Figueroa
A1 Nuria Olivier Pascual
A1 Luiz H Lima
A1 Wael A Alsakran
A1 Sibel Caliskan Kadayifcilar
A1 Suthasinee Sinawat
A1 Alexandre Assi
A1 Hana A Mansour
A1 Antonio Marcello Casella
A1 Amparo Navea
A1 Elena Rodríguez Neila
A1 A Osman Saatci
A1 Vishal Govindahari
A1 Olivia Esteban Floria
A1 Komal Agarwal
A1 Ismael Bakkali El Bakkali
A1 Angel Salinas Alaman
A1 Sofia Fernandez Larripa
A1 Amanda Rey
A1 Patricia Pera
A1 Lluís Bruix
A1 Lorenzo Lopez-Guajardo
A1 Eduardo Pérez-Salvador
A1 Francisco Javier Lara Medina
A1 Frank N Hrisomalos
A1 Jay Chhablani
A1 J Fernando Arevalo
YR 2022
UL http://bjo.bmj.com/content/106/10/1463.abstract
AB Purpose To ascertain the anatomic factors that help achieve non-surgical sealing in full thickness macular hole (FTMH).Methods Retrospective collaborative study of FTMH that closed without surgical intervention.Results A total of 78 patients (mean age 57.9 years) included 18 patients with blunt ocular trauma, 18 patients that received topical or intravitreal therapies and 42 patients with idiopathic FTMH. Mean±SD of the initial corrected visual acuity (VA) in logMAR improved from 0.65±0.54 to 0.34±0.45 (p<0.001) at a mean follow-up of 33.8±37.1 months. FTMH reopened in seven eyes (9.0%) after a mean of 8.6 months. Vitreomacular traction was noted in 12 eyes (15.8%), perifoveal posterior vitreous detachment in 42 (53.8%), foveal epiretinal membrane in 10 (12.8%), cystoid macular oedema (CME) in 49 (62.8%) and subretinal fluid (SRF) in 20 (25.6%). By multivariate analysis, initial VA correlated to the height (p<0.001) and narrowest diameter of the hole (p<0.001) while final VA correlated to the basal diameter (p<0.001). Time for closure of FTMH (median 2.8 months) correlated to the narrowest diameter (p<0.001) and the presence of SRF (p=0.001). Mean time for closure (in months) was 1.6 for eyes with trauma, 4.3 for eyes without trauma but with therapy for CME, 4.4 for eyes without trauma and without therapy in less than 200 µm in size and 24.7 for more than 200 µm.Conclusion Our data suggest an observation period in new onset FTMH for non-surgical closure, in the setting of trauma, treatment of CME and size <200 µm.Data are available upon reasonable request. Data are available upon request by email to the corresponding author.