RT Journal Article
SR Electronic
T1 Electroretinographic findings in retinal vasculitis
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2022-321716
DO 10.1136/bjo-2022-321716
A1 Hashem H Ghoraba
A1 Wataru Matsumiya
A1 Christopher Or
A1 Hasan Khojasteh
A1 Prem Patel
A1 Irmak Karaca
A1 Jonathan Regenold
A1 Moosa Zaidi
A1 Jaclyn Hwang
A1 Sherin Lajevardi
A1 Negin Yavari
A1 Ngoc Trong Tuong Than
A1 Sung Who Park
A1 Amir Akhavanrezayat
A1 Gunay Uludag
A1 Cigdem Yasar
A1 Loh-Shan B Leung
A1 Quan Dong Nguyen
YR 2022
UL http://bjo.bmj.com/content/early/2022/09/20/bjo-2022-321716.abstract
AB Aim To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).Methods Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.Results 20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08–1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0–6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.Conclusion In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.No data are available.