RT Journal Article
SR Electronic
T1 Risk factors for previously undiagnosed primary open-angle glaucoma: the EPIC-Norfolk Eye Study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1684
OP 1688
DO 10.1136/bjophthalmol-2020-317718
VO 106
IS 12
A1 Chan, Michelle P Y
A1 Khawaja, Anthony P
A1 Broadway, David C
A1 Yip, Jennifer
A1 Luben, Robert
A1 Hayat, Shabina
A1 Peto, Tunde
A1 Khaw, Kay-Tee
A1 Foster, Paul J
YR 2022
UL http://bjo.bmj.com/content/106/12/1684.abstract
AB Background and aim Undiagnosed glaucoma is an invisible but important public health issue. At least half of glaucoma cases are estimated to be undiagnosed in western populations. The aim of this study is to examine risk factors for previously undiagnosed primary open-angle glaucoma (POAG).Design Cross-sectional study within the European Prospective Investigation of Cancer-Norfolk Eye Study, a large-scale cohort study in the UK.Participants 314 study participants with POAG in either eye.Methods Logistic regression was used to examine associations with previously undiagnosed POAG compared with previously diagnosed POAG. The factors examined included sociodemographic, ocular, physical and economic factors that could be barriers to eye care access.Results 217 participants had previously diagnosed POAG and 107 participants were newly diagnosed with POAG during the study. After adjusting for covariables, the factors significantly associated with previously undiagnosed POAG were: a lower pretreatment intraocular pressure (IOP) (OR 0.71/mm Hg, 95% CI 0.63 to 0.80, p<0.0001), and to have reported no problems with their eyesight (OR 0.03, 95% CI 0.01 to 0.10, p<0.0001).Conclusions The risk factors for previously undiagnosed POAG identified in this study highlight the over-reliance on IOP level in glaucoma screening and the risk of missing glaucoma among lower IOP cases. It also suggests a role in improving glaucoma awareness in the community.Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. All data relevant to the study are included in the article or uploaded as supplementary information. Data are available upon reasonable request