RT Journal Article
SR Electronic
T1 Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 102
OP 108
DO 10.1136/bjophthalmol-2021-319540
VO 107
IS 1
A1 Jade Y. Moon
A1 Itika Garg
A1 Ying Cui
A1 Raviv Katz
A1 Ying Zhu
A1 Rongrong Le
A1 Yifan Lu
A1 Edward S. Lu
A1 Cassie A. Ludwig
A1 Tobias Elze
A1 David M. Wu
A1 Dean Eliott
A1 Joan W. Miller
A1 Leo A. Kim
A1 Deeba Husain
A1 Demetrios G. Vavvas
A1 John B. Miller
YR 2023
UL http://bjo.bmj.com/content/107/1/102.abstract
AB Background/aims Pathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).Methods This prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.Results This study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=−0.39, βVSD=−10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.Conclusion Using WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.Data are available upon reasonable request. Deidentified participant data used in this study could be shared upon reasonable request sent to the corresponding author.