PT  - JOURNAL ARTICLE
AU  - Murat Hasanreisoglu
AU  - Muhammad Sohail Halim
AU  - Pinar Cakar Ozdal
AU  - Maria Soledad Ormaechea
AU  - Cem Kesim
AU  - Huseyin Baran Ozdemir
AU  - Gunay Uludag
AU  - Nripun Sredar
AU  - Mahmut Cankurtaran
AU  - Xiaoxuan Liu
AU  - Alastair Keith Denniston
AU  - Marcelo N. Rudzinski
AU  - Daniel N. Colombero
AU  - Bernardo Ariel Schlaen
AU  - Pearse Andrew Keane
AU  - Carlos Pavesio
AU  - Quan Dong Nguyen
TI  - Fundus topographical distribution patterns of ocular toxoplasmosis
AID  - 10.1136/bjo-2022-322747
DP  - 2023 Mar 17
TA  - British Journal of Ophthalmology
PG  - bjo-2022-322747
4099  - http://bjo.bmj.com/content/early/2023/03/16/bjo-2022-322747.short
4100  - http://bjo.bmj.com/content/early/2023/03/16/bjo-2022-322747.full
AB  - Background To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions.Methods In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed.Results 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola.Conclusion The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.Data are available upon reasonable request.