RT Journal Article
SR Electronic
T1 Association of hyperopia with incident clinically significant depression: epidemiological and genetic evidence in the middle-aged and older population
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP bjophthalmol-2022-321876
DO 10.1136/bjo-2022-321876
A1 Zijing Du
A1 Xiayin Zhang
A1 Yijun Hu
A1 Yu Huang
A1 Gabriella Bulloch
A1 Xianwen Shang
A1 Yingying Liang
A1 Guanrong Wu
A1 Yaxin Wang
A1 Yu Xiao
A1 Huiqian Kong
A1 Dan Jouma Amadou Maman Lawali
A1 Yunyan Hu
A1 Zhuoting Zhu
A1 Xiaohong Yang
A1 Honghua Yu
YR 2022
UL http://bjo.bmj.com/content/early/2023/05/16/bjo-2022-321876.abstract
AB Aims To investigate the association between hyperopia and clinically significant depression (CSD) in middle-aged and older individuals. The effect of genetic determinants of hyperopia on incident CSD was also explored.Methods We included participants who had available data on mean spherical equivalent (MSE) and were free of depression at baseline from the UK Biobank. For the phenotypic association, hyperopia was defined as MSE of+2.00 dioptres (D) or greater, and was divided into mild, moderate and high groups. Diagnosis of CSD across follow-up was determined based on electronic hospital inpatients records. For the genetic association analysis, the association between hyperopia Polygenic Risk Score and incident CSD was assessed. Mendelian randomisation was assessed for causality association.Results Over a median follow-up of 11.11 years (IQR: 10.92–11.38), hyperopia was significantly associated with incident CSD independent of genetic risk (HR 1.29, 95% CI 1.05 to 1.59) compared with emmetropia participants, especially in those hyperopic patients without optical correction (HR 1.38, 95% CI 1.07 to 1.76). In addition, participants in the high degree of hyperopia were more likely to have incident CSD than participants in the mild degree of hyperopia (P for trend=0.009). Genetic analyses did not show any significant associations between hyperopia and incident CSD (p≥0.1).Conclusions Hyperopia was significantly associated with an increased risk of incident CSD. This was independent of genetic predisposition to hyperopia, emphasising the importance of regular vision screening and correction of hyperopia to reduce the risk of CSD regardless of genetic risk.Data are available in a public, open access repository.