RT Journal Article
SR Electronic
T1 Choroidal thickness in patients with thyroid-associated ophthalmopathy, as determined by swept-source optical coherence tomography
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1081
OP 1087
DO 10.1136/bjo-2023-323694
VO 108
IS 8
A1 Zhong, Sisi
A1 He, Fanglin
A1 Fang, Sijie
A1 Sun, Jing
A1 Li, Yinwei
A1 Shuo, Zhang
A1 Liu, Xingtong
A1 Song, Xuefei
A1 Wang, Yang
A1 Huang, Yazhuo
A1 Zhou, Huifang
A1 Fan, Xianqun
YR 2024
UL http://bjo.bmj.com/content/108/8/1081.abstract
AB Aim This study used swept-source optical coherence tomography (SS-OCT) to investigate subfoveal choroidal thickness (SFCT) in patients with thyroid-associated ophthalmopathy (TAO) who displayed different levels of disease activity and severity.Methods Thirty patients with TAO (60 eyes) and 38 healthy controls (67 eyes) in Shanghai, China, were recruited for this study. Disease activity and severity were graded using European Group on Graves’ Orbitopathy standardised criteria. SFCT values were determined by SS-OCT.Results In total, 129 eyes were included in the final analysis. The mean SFCT was significantly thicker among patients with active disease (276.23±84.01 µm) than among patients with inactive disease (224.68±111.61 µm; p=0.049) or healthy controls (223.56±78.69 µm; p=0.01). There were no differences in SFCT among patients with moderate-to-severe disease, patients with severe disease and healthy controls (p>0.05). Changes in SFCT demonstrated strong predictive ability to distinguish active TAO from inactive TAO (area under the curve=0.659, 95% CI 0.496 to 0.822).Conclusions SFCT was strongly associated with Clinical Activity Score in patients with TAO. Choroidal thickening was observed during active TAO. SS-OCT offers a non-invasive method for follow-up assessment.Data are available on reasonable request.