(A) IgA glomerulonephritis | |||||||||
---|---|---|---|---|---|---|---|---|---|
Patient | Sex | Age | Haem | Pro | BP | Renal function | Cornea | Lens | Retina |
JJ | F | 37 | + | + | ABN | N | N | N | 0 dots |
LJ | F | 64 | + | + | N | N | dots | N | 0 dots |
JB | M | 58 | + | + | N | ABN | N | N | 100 dots |
JM | M | 39 | + | + | N | N | N | N | 0 dots |
FE | F | 46 | + | + | N | ABN | N | N | 0 dots |
FD | F | 38 | − | − | N | N | N | N | 0 dots |
CL | M | 23 | + | − | N | N | N | N | 0 dots |
HP | M | 51 | + | − | N | N | N | N | 0 dots |
TW | M | 51 | + | + | N | ABN | N | N | 0 dots |
GJ | M | 44 | + | + | ABN | ABN | N | N | 1 dot |
FR | F | No further details | N | N | 0.5 dots | ||||
(B) X linked Alport syndrome | |||||||||
Patient | Sex | Age (years) | FH | Hearing | Renal function | Age at renal failure | Cornea | Lens | Retina |
DH | M | 17 | + | Abn | N, haem | NA | Corneal dystrophy | Dots | 1 dot |
PH | F | 45 | + | N | N, haem | NA | Corneal dystrophy | N | 0.5 dot |
JT | F | 46 | + | N | N, haem | NA | N | Opacity | 6 dots |
NH | M | 30 | − | Abn | Transplant | 15 | Dots | Scissor’s reflex | Dots and flecks |
AC | M | 34 | − | Abn | Transplant | 17 | N | N | Dots and flecks |
CH | F | 37 | + | N | N, haem | NA | N | N | 1 dot |
Haem = + RBC greater than × 106/l; Pro = proteinuria + more than 0.3 g/day; BP + = blood pressure more than 140/90 mm Hg; FH = family history; N = normal; Abn = abnormal; NA = not applicable.
↵PH and DH are mother and son; electron microscopy of PH’s renal biopsy was typical of Alport syndrome, but DH has not had a biopsy.