Table 1

Interphotoreceptor retinoid binding protein (IRBP) suppresses clinical and histological responses in IRBP induced experimental autoimmune uveoretinitis (EAU)

Tolerising antigen Incidence (eyes) Clinical score Histological score
IRBP (50 μg/ml)8/81.751.6*
IRBP (10 μg/ml)8/82.53
RE (4.5 mg/ml)8/82.753.25
  • Animals were immunised subcutaneously with 100 μg of IRBP w/v complete Freund’s adjuvant. Maximal clinical and histological scores represent the median score derived from separate analysis of all eyes. Median histology scores were derived 16 days after immunisation.

  • RE = retinal extract; PBS = phosphate buffered saline.

  • Statistically significant suppression of EAU histologically compared with control animals (PBS). *p<0.005. p<0.02.